2flb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2flb.gif|left|200px]]<br /><applet load="2flb" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2flb.gif|left|200px]]
-
caption="2flb, resolution 1.95&Aring;" />
+
 
-
'''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''<br />
+
{{Structure
 +
|PDB= 2flb |SIZE=350|CAPTION= <scene name='initialview01'>2flb</scene>, resolution 1.95&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=6NH:2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE'>6NH</scene>
 +
|ACTIVITY=
 +
|GENE= F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), F3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
}}
 +
 
 +
'''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''
 +
 
==Overview==
==Overview==
Line 10: Line 19:
==About this Structure==
==About this Structure==
-
2FLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=6NH:'>6NH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLB OCA].
+
2FLB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLB OCA].
==Reference==
==Reference==
-
Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16487703 16487703]
+
Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16487703 16487703]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 22: Line 31:
[[Category: short hydrogen bond-mediated]]
[[Category: short hydrogen bond-mediated]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:22:40 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:53:47 2008''

Revision as of 14:53, 20 March 2008

Image:2flb.gif


PDB ID 2flb

Drag the structure with the mouse to rotate
, resolution 1.95Å
Ligands:
Gene: F7 (Homo sapiens), F3 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor


Contents

Overview

Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.

Disease

Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2FLB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:16487703

Page seeded by OCA on Thu Mar 20 16:53:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2flb"
Personal tools