4in3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4in3| PDB=4in3 | SCENE= }}
+
==Crystal Structure of the Chs5-Bch1 Exomer Cargo Adaptor Complex==
-
===Crystal Structure of the Chs5-Bch1 Exomer Cargo Adaptor Complex===
+
<StructureSection load='4in3' size='340' side='right' caption='[[4in3]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_23395181}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4in3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Streptomyces_aureorectus Streptomyces aureorectus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IN3 FirstGlance]. <br>
 +
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHS5, CAL3, YLR330W, L8543.18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285571 Streptomyces aureorectus]), BCH1, YMR237W, YM9959.19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4in3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4in3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4in3 RCSB], [http://www.ebi.ac.uk/pdbsum/4in3 PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/CHS5_YEAST CHS5_YEAST]] Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. Also involved in targeting FUS1 to sites of polarized growth.<ref>PMID:9111317</ref> <ref>PMID:8197125</ref> <ref>PMID:12912901</ref> <ref>PMID:15715908</ref> <ref>PMID:16498409</ref> <ref>PMID:16818716</ref> <ref>PMID:17000877</ref> <ref>PMID:16855022</ref> [[http://www.uniprot.org/uniprot/BCH1_YEAST BCH1_YEAST]] Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.<ref>PMID:16498409</ref> <ref>PMID:17000877</ref> <ref>PMID:16855022</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Exomer is a cargo adaptor that mediates the sorting of specific plasma membrane proteins into vesicles at the trans-Golgi network. Cargo adaptors must bind to multiple partners, including their cargo, regulatory proteins, and the membrane surface. During biogenesis of a vesicle, the membrane makes a transition from a relatively flat surface to one of high curvature, requiring cargo adaptors to somehow maintain protein-protein and protein-membrane interactions on a changing membrane environment. Here, we present the crystal structure of a tetrameric Chs5/Bch1 exomer complex and use small-angle X-ray scattering to demonstrate its flexibility in solution. The structural data suggest that the complex flexes primarily around the dimeric N-terminal domain of the Chs5 subunits, which adopts a noncanonical beta sandwich fold. We propose that this flexible hinge domain enables exomer to maintain interactions in the context of a dynamic membrane environment.
-
==Function==
+
The Exomer Cargo Adaptor Features a Flexible Hinge Domain.,Richardson BC, Fromme JC Structure. 2013 Feb 5. pii: S0969-2126(13)00006-3. doi:, 10.1016/j.str.2013.01.003. PMID:23395181<ref>PMID:23395181</ref>
-
[[http://www.uniprot.org/uniprot/CHS5_YEAST CHS5_YEAST]] Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. Also involved in targeting FUS1 to sites of polarized growth.<ref>PMID:9111317</ref><ref>PMID:8197125</ref><ref>PMID:12912901</ref><ref>PMID:15715908</ref><ref>PMID:16498409</ref><ref>PMID:16818716</ref><ref>PMID:17000877</ref><ref>PMID:16855022</ref> [[http://www.uniprot.org/uniprot/BCH1_YEAST BCH1_YEAST]] Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.<ref>PMID:16498409</ref><ref>PMID:17000877</ref><ref>PMID:16855022</ref>
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[4in3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Streptomyces_aureorectus Streptomyces aureorectus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IN3 OCA].
+
</div>
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<references group="xtra"/><references/>
+
__TOC__
 +
</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Streptomyces aureorectus]]
[[Category: Streptomyces aureorectus]]
-
[[Category: Fromme, J C.]]
+
[[Category: Fromme, J C]]
-
[[Category: Richardson, B C.]]
+
[[Category: Richardson, B C]]
[[Category: Ob fold]]
[[Category: Ob fold]]
[[Category: Protein transport]]
[[Category: Protein transport]]

Revision as of 22:19, 25 December 2014

Crystal Structure of the Chs5-Bch1 Exomer Cargo Adaptor Complex

4in3, resolution 2.94Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4in3"
Personal tools