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4in3

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{{STRUCTURE_4in3| PDB=4in3 | SCENE= }}
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==Crystal Structure of the Chs5-Bch1 Exomer Cargo Adaptor Complex==
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===Crystal Structure of the Chs5-Bch1 Exomer Cargo Adaptor Complex===
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<StructureSection load='4in3' size='340' side='right' caption='[[4in3]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23395181}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4in3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Streptomyces_aureorectus Streptomyces aureorectus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IN3 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHS5, CAL3, YLR330W, L8543.18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285571 Streptomyces aureorectus]), BCH1, YMR237W, YM9959.19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4in3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4in3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4in3 RCSB], [http://www.ebi.ac.uk/pdbsum/4in3 PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CHS5_YEAST CHS5_YEAST]] Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. Also involved in targeting FUS1 to sites of polarized growth.<ref>PMID:9111317</ref> <ref>PMID:8197125</ref> <ref>PMID:12912901</ref> <ref>PMID:15715908</ref> <ref>PMID:16498409</ref> <ref>PMID:16818716</ref> <ref>PMID:17000877</ref> <ref>PMID:16855022</ref> [[http://www.uniprot.org/uniprot/BCH1_YEAST BCH1_YEAST]] Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.<ref>PMID:16498409</ref> <ref>PMID:17000877</ref> <ref>PMID:16855022</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Exomer is a cargo adaptor that mediates the sorting of specific plasma membrane proteins into vesicles at the trans-Golgi network. Cargo adaptors must bind to multiple partners, including their cargo, regulatory proteins, and the membrane surface. During biogenesis of a vesicle, the membrane makes a transition from a relatively flat surface to one of high curvature, requiring cargo adaptors to somehow maintain protein-protein and protein-membrane interactions on a changing membrane environment. Here, we present the crystal structure of a tetrameric Chs5/Bch1 exomer complex and use small-angle X-ray scattering to demonstrate its flexibility in solution. The structural data suggest that the complex flexes primarily around the dimeric N-terminal domain of the Chs5 subunits, which adopts a noncanonical beta sandwich fold. We propose that this flexible hinge domain enables exomer to maintain interactions in the context of a dynamic membrane environment.
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==Function==
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The Exomer Cargo Adaptor Features a Flexible Hinge Domain.,Richardson BC, Fromme JC Structure. 2013 Feb 5. pii: S0969-2126(13)00006-3. doi:, 10.1016/j.str.2013.01.003. PMID:23395181<ref>PMID:23395181</ref>
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[[http://www.uniprot.org/uniprot/CHS5_YEAST CHS5_YEAST]] Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. Also involved in targeting FUS1 to sites of polarized growth.<ref>PMID:9111317</ref><ref>PMID:8197125</ref><ref>PMID:12912901</ref><ref>PMID:15715908</ref><ref>PMID:16498409</ref><ref>PMID:16818716</ref><ref>PMID:17000877</ref><ref>PMID:16855022</ref> [[http://www.uniprot.org/uniprot/BCH1_YEAST BCH1_YEAST]] Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.<ref>PMID:16498409</ref><ref>PMID:17000877</ref><ref>PMID:16855022</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4in3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Streptomyces_aureorectus Streptomyces aureorectus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IN3 OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Streptomyces aureorectus]]
[[Category: Streptomyces aureorectus]]
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[[Category: Fromme, J C.]]
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[[Category: Fromme, J C]]
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[[Category: Richardson, B C.]]
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[[Category: Richardson, B C]]
[[Category: Ob fold]]
[[Category: Ob fold]]
[[Category: Protein transport]]
[[Category: Protein transport]]

Revision as of 22:19, 25 December 2014

Crystal Structure of the Chs5-Bch1 Exomer Cargo Adaptor Complex

4in3, resolution 2.94Å

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