2ww9
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ww9]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WW9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ww9]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WW9 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k5y|1k5y]], [[1s1i|1s1i]], [[2wwa|2wwa]], [[2wwb|2wwb]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k5y|1k5y]], [[1s1i|1s1i]], [[2wwa|2wwa]], [[2wwb|2wwb]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ww9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ww9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ww9 RCSB], [http://www.ebi.ac.uk/pdbsum/2ww9 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ww9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ww9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ww9 RCSB], [http://www.ebi.ac.uk/pdbsum/2ww9 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/SC6B2_YEAST SC6B2_YEAST]] Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import. [[http://www.uniprot.org/uniprot/SC61G_YEAST SC61G_YEAST]] Part of the Sec61 complex, which is the major component of channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. Also part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein ER import.[HAMAP-Rule:MF_00422] [[http://www.uniprot.org/uniprot/RL4B_YEAST RL4B_YEAST]] Participates in the regulation of the accumulation of its own mRNA. [[http://www.uniprot.org/uniprot/SSH1_YEAST SSH1_YEAST]] Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 39: | Line 41: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Armache, J P | + | [[Category: Armache, J P]] |
| - | [[Category: Becker, T | + | [[Category: Becker, T]] |
| - | [[Category: Beckmann, R | + | [[Category: Beckmann, R]] |
| - | [[Category: Berninghausen, O | + | [[Category: Berninghausen, O]] |
| - | [[Category: Bhushan, S | + | [[Category: Bhushan, S]] |
| - | [[Category: Funes, S | + | [[Category: Funes, S]] |
| - | [[Category: Gilmore, R | + | [[Category: Gilmore, R]] |
| - | [[Category: Gumbart, J | + | [[Category: Gumbart, J]] |
| - | [[Category: Jarasch, A | + | [[Category: Jarasch, A]] |
| - | [[Category: Jossinet, F | + | [[Category: Jossinet, F]] |
| - | [[Category: Mandon, E | + | [[Category: Mandon, E]] |
| - | [[Category: Mielke, T | + | [[Category: Mielke, T]] |
| - | [[Category: Schulten, K | + | [[Category: Schulten, K]] |
| - | [[Category: Westhof, E | + | [[Category: Westhof, E]] |
[[Category: Cotranslational protein translocation]] | [[Category: Cotranslational protein translocation]] | ||
[[Category: Endoplasmic reticulum]] | [[Category: Endoplasmic reticulum]] | ||
Revision as of 22:20, 25 December 2014
CRYO-EM STRUCTURE OF THE ACTIVE YEAST SSH1 COMPLEX BOUND TO THE YEAST 80S RIBOSOME
| |||||||||||
Categories: Saccharomyces cerevisiae | Armache, J P | Becker, T | Beckmann, R | Berninghausen, O | Bhushan, S | Funes, S | Gilmore, R | Gumbart, J | Jarasch, A | Jossinet, F | Mandon, E | Mielke, T | Schulten, K | Westhof, E | Cotranslational protein translocation | Endoplasmic reticulum | Isopeptide bond | Membrane | Phosphoprotein | Protein conducting channel | Protein exit tunnel | Protein transport | Ribonucleoprotein | Ribosomal protein | Ribosome | Rna-binding | Rrna-binding | Signal sequence | Translocation | Transmembrane | Transport
