4ajd

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[[Image:4ajd.jpg|left|200px]]
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==Identification and structural characterization of PDE10 fragment inhibitors==
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<StructureSection load='4ajd' size='340' side='right' caption='[[4ajd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ajd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F04:2-ETHYL-4-METHYL-PHTHALAZIN-1-ONE'>F04</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajf|4ajf]], [[4ajg|4ajg]], [[4ajm|4ajm]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ajd RCSB], [http://www.ebi.ac.uk/pdbsum/4ajd PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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{{STRUCTURE_4ajd| PDB=4ajd | SCENE= }}
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==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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===Identification and structural characterization of PDE10 fragment inhibitors===
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== References ==
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4ajd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJD OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aharony, D.]]
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[[Category: Aharony, D]]
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[[Category: Akerud, T.]]
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[[Category: Akerud, T]]
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[[Category: Albert, J S.]]
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[[Category: Albert, J S]]
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[[Category: Back, E.]]
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[[Category: Back, E]]
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[[Category: Geschwindner, S.]]
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[[Category: Geschwindner, S]]
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[[Category: Hillertz, P.]]
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[[Category: Hillertz, P]]
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[[Category: Horsefeld, R.]]
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[[Category: Horsefeld, R]]
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[[Category: Johansson, P.]]
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[[Category: Johansson, P]]
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[[Category: Scott, C.]]
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[[Category: Scott, C]]
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[[Category: Spadola, L.]]
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[[Category: Spadola, L]]
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[[Category: Spear, N.]]
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[[Category: Spear, N]]
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[[Category: Tian, G.]]
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[[Category: Tian, G]]
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[[Category: Tigerstrom, A.]]
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[[Category: Tigerstrom, A]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 22:25, 25 December 2014

Identification and structural characterization of PDE10 fragment inhibitors

4ajd, resolution 2.30Å

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