2y77
From Proteopedia
(Difference between revisions)
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<StructureSection load='2y77' size='340' side='right' caption='[[2y77]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2y77' size='340' side='right' caption='[[2y77]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y77]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y77 OCA]. <br> | + | <table><tr><td colspan='2'>[[2y77]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y77 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y77 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB8:(1R,4S,5R)-3-(BENZO[B]THIOPHEN-2-YL)METHOXY-1,4,5-TRIHYDROXY-2-(THIEN-2-YL)METHYLCYCLOHEX-2-EN-1-CARBOXYLATE'>CB8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB8:(1R,4S,5R)-3-(BENZO[B]THIOPHEN-2-YL)METHOXY-1,4,5-TRIHYDROXY-2-(THIEN-2-YL)METHYLCYCLOHEX-2-EN-1-CARBOXYLATE'>CB8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h0r|1h0r]], [[2xb8|2xb8]], [[2y71|2y71]], [[1h05|1h05]], [[2dhq|2dhq]], [[1h0s|1h0s]], [[2y76|2y76]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h0r|1h0r]], [[2xb8|2xb8]], [[2y71|2y71]], [[1h05|1h05]], [[2dhq|2dhq]], [[1h0s|1h0s]], [[2y76|2y76]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y77 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y77 RCSB], [http://www.ebi.ac.uk/pdbsum/2y77 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y77 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y77 RCSB], [http://www.ebi.ac.uk/pdbsum/2y77 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors.,Tizon L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, Gonzalez-Bello C J Med Chem. 2011 Aug 3. PMID:21780742<ref>PMID:21780742</ref> | A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors.,Tizon L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, Gonzalez-Bello C J Med Chem. 2011 Aug 3. PMID:21780742<ref>PMID:21780742</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dehydroquinase|Dehydroquinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: 3-dehydroquinate dehydratase]] | [[Category: 3-dehydroquinate dehydratase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: Ainsa, J A | + | [[Category: Ainsa, J A]] |
| - | [[Category: Castedo, L | + | [[Category: Castedo, L]] |
| - | [[Category: Fox, G C | + | [[Category: Fox, G C]] |
| - | [[Category: Gonzalez-Bello, C | + | [[Category: Gonzalez-Bello, C]] |
| - | [[Category: Hawkins, A R | + | [[Category: Hawkins, A R]] |
| - | [[Category: Lamb, H | + | [[Category: Lamb, H]] |
| - | [[Category: Llamas-Saiz, A L | + | [[Category: Llamas-Saiz, A L]] |
| - | [[Category: Otero, J M | + | [[Category: Otero, J M]] |
| - | [[Category: Prazeres, V F.V | + | [[Category: Prazeres, V F.V]] |
| - | [[Category: Raaij, M J.Van | + | [[Category: Raaij, M J.Van]] |
| - | [[Category: Tizon, L | + | [[Category: Tizon, L]] |
[[Category: Amino acid biosynthesis]] | [[Category: Amino acid biosynthesis]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
Revision as of 22:31, 25 December 2014
STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TYPE II DEHYDROQUINASE COMPLEXED WITH (1R,4S,5R)-3-(BENZO(B) THIOPHEN-2-YLMETHOXY)-1,4,5-TRIHYDROXY-2-(THIOPHEN-2-YLMETHYL)CYCLOHEX-2-ENECARBOXYLATE
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