4oaj

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{{STRUCTURE_4oaj| PDB=4oaj | SCENE= }}
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==Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide==
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===Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide===
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<StructureSection load='4oaj' size='340' side='right' caption='[[4oaj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4oaj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OAJ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dlg1, Dlgh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oaj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oaj RCSB], [http://www.ebi.ac.uk/pdbsum/4oaj PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/DLG1_MOUSE DLG1_MOUSE]] Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels (By similarity). Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.<ref>PMID:11238884</ref> [[http://www.uniprot.org/uniprot/5HT2A_RAT 5HT2A_RAT]] G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.<ref>PMID:2300586</ref> <ref>PMID:2854054</ref>
[[http://www.uniprot.org/uniprot/DLG1_MOUSE DLG1_MOUSE]] Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels (By similarity). Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.<ref>PMID:11238884</ref> [[http://www.uniprot.org/uniprot/5HT2A_RAT 5HT2A_RAT]] G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.<ref>PMID:2300586</ref> <ref>PMID:2854054</ref>
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== References ==
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==About this Structure==
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<references/>
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[[4oaj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OAJ OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Lk3 transgenic mice]]
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<references group="xtra"/><references/>
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[[Category: Dorr, L]]
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[[Category: Dorr, L.]]
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[[Category: Lian, L-Y]]
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[[Category: Lian, L-Y.]]
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[[Category: Mayans, O]]
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[[Category: Mayans, O.]]
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[[Category: Pandalaneni, S]]
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[[Category: Pandalaneni, S.]]
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[[Category: 5ht2a receptor]]
[[Category: 5ht2a receptor]]
[[Category: Pdz domain]]
[[Category: Pdz domain]]
[[Category: Protein binding]]
[[Category: Protein binding]]

Revision as of 22:37, 25 December 2014

Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide

4oaj, resolution 2.30Å

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