4g2v

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{{STRUCTURE_4g2v| PDB=4g2v | SCENE= }}
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==Structure complex of LGN binding with FRMPD1==
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===Structure complex of LGN binding with FRMPD1===
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<StructureSection load='4g2v' size='340' side='right' caption='[[4g2v]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23318951}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g2v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2V FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2v RCSB], [http://www.ebi.ac.uk/pdbsum/4g2v PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE]] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. [[http://www.uniprot.org/uniprot/FRPD1_HUMAN FRPD1_HUMAN]] Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.<ref>PMID:18566450</ref>
[[http://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE]] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. [[http://www.uniprot.org/uniprot/FRPD1_HUMAN FRPD1_HUMAN]] Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.<ref>PMID:18566450</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The tetratricopeptide repeat (TPR) motif-containing protein LGN binds multiple targets and regulates their subcellular localizations and functions during both asymmetric and symmetric cell divisions. Here, we characterized the interaction between LGN-TPR motifs and FERM and PDZ domain containing 1 (Frmpd1) and reported the crystal structure of the complex at 2.4A resolution. A highly conserved fragment at the center of Frmpd1 of ~20 residues was found to be necessary and sufficient to bind to LGN-TPR. This Frmpd1 fragment forms an extended structure and runs along the concave channel of the TPR superhelix in an antiparallel manner in the complex. Structural comparisons and biochemical studies of LGN/Frmpd1 and other known LGN/target interactions demonstrate that the LGN-TPR motifs are versatile and capable of recognizing multiple targets via diverse binding modes. Nevertheless, a conserved "E/QxEx4-5E/D/Qx1-2K/R" motif in LGN/Pins (partner of inscuteable) TPR binding proteins has been identified.
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==About this Structure==
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Structural and biochemical characterization of the interaction between LGN and Frmpd1.,Pan Z, Shang Y, Jia M, Zhang L, Xia C, Zhang M, Wang W, Wen W J Mol Biol. 2013 Mar 25;425(6):1039-49. doi: 10.1016/j.jmb.2013.01.003. Epub 2013, Jan 11. PMID:23318951<ref>PMID:23318951</ref>
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[[4g2v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2V OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023318951</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Pan, Z.]]
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[[Category: Pan, Z]]
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[[Category: Shang, Y.]]
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[[Category: Shang, Y]]
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[[Category: Wang, W.]]
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[[Category: Wang, W]]
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[[Category: Wen, W.]]
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[[Category: Wen, W]]
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[[Category: Zhang, M.]]
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[[Category: Zhang, M]]
[[Category: Cell polarity]]
[[Category: Cell polarity]]
[[Category: Lgn]]
[[Category: Lgn]]
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Tpr repeat]]
[[Category: Tpr repeat]]

Revision as of 22:48, 25 December 2014

Structure complex of LGN binding with FRMPD1

4g2v, resolution 2.40Å

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