Nucleosome structure
From Proteopedia
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== References == | == References == | ||
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| + | This page is based on [[1aoi]]file from Proteopedia | ||
[[1aoi]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The July 2000 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nucleosome'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2000_7 10.2210/rcsb_pdb/mom_2000_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AOI FirstGlance]. | [[1aoi]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The July 2000 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nucleosome'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2000_7 10.2210/rcsb_pdb/mom_2000_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AOI FirstGlance]. | ||
Revision as of 10:03, 27 December 2014
La unidad básica de la cromatina: el nucleosoma
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El nucleosoma es la estructura básica de la fibra de cromatina. Un nucleosoma está constituido por un octámero de proteínas histónicas en su parte central y una doble hélice de DNA de 146 pares de bases de longitud que da dos vueltas casi completas alrededor de dicho octámero. En el recuadro de la derecha se puede apreciar el octámero de histonas. El octámero de histonas está formado por cuatro tipos de histonas diferentes: , , y (hay dos moléculas de cada tipo). Los diferentes tipos de histonas están dispuestos en dímeros del siguiente modo:
- Dos dímeros H3-H4
- Dos dímeros H2A-H2B
Veamos ahora el completo. La doble cadena polinucleotídica de se dispone dando alrededor del octámero de histonas.
</StructureSection>
References
This page is based on 1aoifile from Proteopedia 1aoi is a 10 chain structure with sequence from Xenopus laevis. The July 2000 RCSB PDB Molecule of the Month feature on Nucleosome by David S. Goodsell is 10.2210/rcsb_pdb/mom_2000_7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
