2fqn
From Proteopedia
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| - | [[Image:2fqn.gif|left|200px]] | + | [[Image:2fqn.gif|left|200px]] |
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| - | '''Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site''' | + | {{Structure |
| + | |PDB= 2fqn |SIZE=350|CAPTION= <scene name='initialview01'>2fqn</scene>, resolution 2.300Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=NCO:COBALT HEXAMMINE ION'>NCO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2FQN is a [ | + | 2FQN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQN OCA]. |
==Reference== | ==Reference== | ||
| - | Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site., Kondo J, Urzhumtsev A, Westhof E, Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:[http:// | + | Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site., Kondo J, Urzhumtsev A, Westhof E, Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16452297 16452297] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Kondo, J.]] | [[Category: Kondo, J.]] | ||
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[[Category: rrna]] | [[Category: rrna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:55:40 2008'' |
Revision as of 14:55, 20 March 2008
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| , resolution 2.300Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site
Overview
The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493.
About this Structure
2FQN is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site., Kondo J, Urzhumtsev A, Westhof E, Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:16452297
Page seeded by OCA on Thu Mar 20 16:55:40 2008
Categories: Protein complex | Kondo, J. | Urzhumtsev, A. | Westhof, E. | MG | NCO | A site | Decoding site | Homo sapiens cytoplasm | Rna duplex | Rrna
