2fw3
From Proteopedia
(Difference between revisions)
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| - | [[Image:2fw3.gif|left|200px]] | + | [[Image:2fw3.gif|left|200px]] |
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| - | '''Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326''' | + | {{Structure |
| + | |PDB= 2fw3 |SIZE=350|CAPTION= <scene name='initialview01'>2fw3</scene>, resolution 2.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=BUI:(3R)-3-{[(TETRADECYLAMINO)CARBONYL]AMINO}-4-(TRIMETHYLAMMONIO)BUTANOATE'>BUI</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2FW3 is a [ | + | 2FW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FW3 OCA]. |
==Reference== | ==Reference== | ||
| - | A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:[http:// | + | A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16615901 16615901] |
[[Category: Carnitine O-palmitoyltransferase]] | [[Category: Carnitine O-palmitoyltransferase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
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[[Category: central six-stranded beta-sheet]] | [[Category: central six-stranded beta-sheet]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:57:24 2008'' |
Revision as of 14:57, 20 March 2008
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| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Carnitine O-palmitoyltransferase, with EC number 2.3.1.21 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326
Overview
Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
About this Structure
2FW3 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:16615901
Page seeded by OCA on Thu Mar 20 16:57:24 2008
