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4rv8
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(Difference between revisions)
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| - | ''' | + | ==Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131== |
| - | + | <StructureSection load='4rv8' size='340' side='right' caption='[[4rv8]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rv8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=I13:1-(2-{3-[(1E)-N-(2-AMINOETHOXY)ETHANIMIDOYL]PHENYL}PROPAN-2-YL)-3-(4-CHLORO-3-NITROPHENYL)UREA'>I13</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ffs|3ffs]], [[4ixh|4ixh]]</td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv8 PDBsum]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: IMP dehydrogenase]] | ||
| + | [[Category: Andesrson, W F]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Gu, M]] | [[Category: Gu, M]] | ||
| - | [[Category: | + | [[Category: Hedstrom, L]] |
| + | [[Category: Joachimiak, A]] | ||
| + | [[Category: Kavitha, M]] | ||
[[Category: Kim, Y]] | [[Category: Kim, Y]] | ||
| + | [[Category: Makowska-Grzyska, M]] | ||
| + | [[Category: Alpha-beta fold]] | ||
| + | [[Category: Csgid]] | ||
| + | [[Category: National institute of allergy and infectious disease]] | ||
| + | [[Category: Niaid]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Tim barrel]] | ||
Revision as of 14:54, 31 December 2014
Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131
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