2fxk

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[[Image:2fxk.gif|left|200px]]<br /><applet load="2fxk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2fxk.gif|left|200px]]
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caption="2fxk, resolution 2.54&Aring;" />
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'''Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)'''<br />
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{{Structure
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|PDB= 2fxk |SIZE=350|CAPTION= <scene name='initialview01'>2fxk</scene>, resolution 2.54&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2FXK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1ZQ0. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXK OCA].
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2FXK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1ZQ0. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXK OCA].
==Reference==
==Reference==
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Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15965484 15965484]
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Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15965484 15965484]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: p-loop]]
[[Category: p-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:57:56 2008''

Revision as of 14:57, 20 March 2008

Image:2fxk.gif


PDB ID 2fxk

Drag the structure with the mouse to rotate
, resolution 2.54Å
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)


Overview

Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in the gene H2AFY produces macroH2A1.2, whose tissue distribution differs. MacroH2A1.2 shows only subtle structural changes but cannot bind nucleotides. Alternative splicing may thus regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.

About this Structure

2FXK is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1ZQ0. Full crystallographic information is available from OCA.

Reference

Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:15965484

Page seeded by OCA on Thu Mar 20 16:57:56 2008

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