1ig6
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ig6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bmy 1bmy]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IG6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ig6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bmy 1bmy]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IG6 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bmy|1bmy]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bmy|1bmy]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MRF-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MRF-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ig6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ig6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ig6 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ig6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ig6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ig6 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/ARI5B_HUMAN ARI5B_HUMAN]] Note=Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese population. Defects in ARID5B may be a cause of susceptibility to acute lymphoblastic leukemia (ALL) [MIM:[http://omim.org/entry/613065 613065]]. Note=ALL is a subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphonodes.<ref>PMID:19684603</ref> <ref>PMID:19684604</ref> <ref>PMID:20042726</ref> <ref>PMID:20460642</ref> <ref>PMID:20054350</ref> <ref>PMID:20189245</ref> <ref>PMID:21098271</ref> | [[http://www.uniprot.org/uniprot/ARI5B_HUMAN ARI5B_HUMAN]] Note=Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese population. Defects in ARID5B may be a cause of susceptibility to acute lymphoblastic leukemia (ALL) [MIM:[http://omim.org/entry/613065 613065]]. Note=ALL is a subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphonodes.<ref>PMID:19684603</ref> <ref>PMID:19684604</ref> <ref>PMID:20042726</ref> <ref>PMID:20460642</ref> <ref>PMID:20054350</ref> <ref>PMID:20189245</ref> <ref>PMID:21098271</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Case, D | + | [[Category: Case, D]] |
| - | [[Category: Chen, Y | + | [[Category: Chen, Y]] |
| - | [[Category: Lin, D | + | [[Category: Lin, D]] |
| - | [[Category: Tsui, V | + | [[Category: Tsui, V]] |
| - | [[Category: Yuan, Y C | + | [[Category: Yuan, Y C]] |
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Dna-binding motif]] | [[Category: Dna-binding motif]] | ||
[[Category: Mrf-2]] | [[Category: Mrf-2]] | ||
[[Category: Protein-dna interaction]] | [[Category: Protein-dna interaction]] | ||
Revision as of 09:46, 2 January 2015
HUMAN MRF-2 DOMAIN, NMR, 11 STRUCTURES
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