2g0d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2g0d.gif|left|200px]]<br /><applet load="2g0d" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2g0d.gif|left|200px]]
-
caption="2g0d, resolution 2.21&Aring;" />
+
 
-
'''Nisin cyclase'''<br />
+
{{Structure
 +
|PDB= 2g0d |SIZE=350|CAPTION= <scene name='initialview01'>2g0d</scene>, resolution 2.21&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
 +
|ACTIVITY=
 +
|GENE= nisC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1360 Lactococcus lactis subsp. lactis])
 +
}}
 +
 
 +
'''Nisin cyclase'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
2G0D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0D OCA].
+
2G0D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0D OCA].
==Reference==
==Reference==
-
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16527981 16527981]
+
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16527981 16527981]
[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 18: Line 27:
[[Category: alpha toroid]]
[[Category: alpha toroid]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:56 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:58:56 2008''

Revision as of 14:58, 20 March 2008

Image:2g0d.gif


PDB ID 2g0d

Drag the structure with the mouse to rotate
, resolution 2.21Å
Ligands:
Gene: nisC (Lactococcus lactis subsp. lactis)
Coordinates: save as pdb, mmCIF, xml



Nisin cyclase


Overview

Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.

About this Structure

2G0D is a Single protein structure of sequence from Lactococcus lactis subsp. lactis. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:16527981

Page seeded by OCA on Thu Mar 20 16:58:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2g0d"
Personal tools