3j3z

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{{STRUCTURE_3j3z| PDB=3j3z | SCENE= }}
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==Structure of MA28-7 neutralizing antibody Fab fragment from electron cryo-microscopy of enterovirus 71 complexed with a Fab fragment==
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===Structure of MA28-7 neutralizing antibody Fab fragment from electron cryo-microscopy of enterovirus 71 complexed with a Fab fragment===
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<StructureSection load='3j3z' size='340' side='right' caption='[[3j3z]], [[Resolution|resolution]] 23.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23946455}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j3z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J3Z FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j3z RCSB], [http://www.ebi.ac.uk/pdbsum/3j3z PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enterovirus 71 (EV71) is a picornavirus that causes outbreaks of hand foot and mouth disease (HFMD) primarily in the Asia-Pacific area. Unlike coxsackievirus A16, which also causes HFMD, EV71 induces severe neuropathology leading to high fatalities especially among children under the age of 6 years. Currently, no established vaccines or treatments are available against EV71 infection. The monoclonal antibody (MAb), MA28-7, neutralizes only specific strains of EV71 that have a conserved glycine at amino acid, VP1-145, a surface exposed residue that maps to the five-fold vertex, and has been implicated in receptor binding. The cryo-electron microscopy structure of a complex between EV71 and the Fab fragment of MA28-7 shows that only one Fab occupies each five-fold vertex. A positively-charged patch, which has also been implicated in receptor binding lies within the Fab footprint. We identify the strain-specific epitope of EV71 and discuss the possible neutralization mechanisms of the antibody.
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==About this Structure==
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A strain-specific epitope of Enterovirus 71 identified by cryoEM of the complex with Fab from neutralizing antibody.,Lee H, Cifuente JO, Ashley RE, Conway JF, Makhov AM, Tano Y, Shimizu H, Nishimura Y, Hafenstein S J Virol. 2013 Aug 14. PMID:23946455<ref>PMID:23946455</ref>
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[[3j3z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J3Z OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023946455</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ashley, R E.]]
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[[Category: Ashley, R E]]
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[[Category: Cifuente, J O.]]
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[[Category: Cifuente, J O]]
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[[Category: Conway, J F.]]
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[[Category: Conway, J F]]
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[[Category: Hafenstein, S.]]
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[[Category: Hafenstein, S]]
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[[Category: Lee, H.]]
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[[Category: Lee, H]]
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[[Category: Makhov, A M.]]
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[[Category: Makhov, A M]]
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[[Category: Nishimura, Y.]]
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[[Category: Nishimura, Y]]
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[[Category: Shimizu, H.]]
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[[Category: Shimizu, H]]
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[[Category: Tano, Y.]]
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[[Category: Tano, Y]]
[[Category: Enterovirus]]
[[Category: Enterovirus]]
[[Category: Ev71]]
[[Category: Ev71]]

Revision as of 21:23, 3 January 2015

Structure of MA28-7 neutralizing antibody Fab fragment from electron cryo-microscopy of enterovirus 71 complexed with a Fab fragment

3j3z, resolution 23.40Å

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