2g6w
From Proteopedia
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| - | [[Image:2g6w.gif|left|200px]] | + | [[Image:2g6w.gif|left|200px]] |
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| - | '''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine''' | + | {{Structure |
| + | |PDB= 2g6w |SIZE=350|CAPTION= <scene name='initialview01'>2g6w</scene>, resolution 2.14Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=LLF:(4-{(E)-[(2,2-DIFLUOROETHYL)IMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE'>LLF</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2G6W is a [ | + | 2G6W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6W OCA]. |
==Reference== | ==Reference== | ||
| - | Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:[http:// | + | Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16557306 16557306] |
[[Category: 8-amino-7-oxononanoate synthase]] | [[Category: 8-amino-7-oxononanoate synthase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
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[[Category: synthase]] | [[Category: synthase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:01:07 2008'' |
Revision as of 15:01, 20 March 2008
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| , resolution 2.14Å | |||||||
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| Ligands: | |||||||
| Activity: | 8-amino-7-oxononanoate synthase, with EC number 2.3.1.47 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine
Overview
The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.
About this Structure
2G6W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:16557306
Page seeded by OCA on Thu Mar 20 17:01:07 2008
