3qsc
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3qsc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QSC FirstGlance]. <br> | <table><tr><td colspan='2'>[[3qsc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QSC FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CUF:[2,2-{(4,5-DIFLUOROBENZENE-1,2-DIYL)BIS[(NITRILO-KAPPAN)METHYLYLIDENE]}BIS{5-[2-(PIPERIDIN-1-YL)ETHOXY]PHENOLATO-KAPPAO}(2-)]COPPER+(II)'>CUF</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CUF:[2,2-{(4,5-DIFLUOROBENZENE-1,2-DIYL)BIS[(NITRILO-KAPPAN)METHYLYLIDENE]}BIS{5-[2-(PIPERIDIN-1-YL)ETHOXY]PHENOLATO-KAPPAO}(2-)]COPPER+(II)'>CUF</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ce5|3ce5]], [[3cco|3cco]], [[3cdm|3cdm]], [[1kf1|1kf1]], [[1k8p|1k8p]], [[2hri|2hri]], [[3qsf|3qsf]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ce5|3ce5]], [[3cco|3cco]], [[3cdm|3cdm]], [[1kf1|1kf1]], [[1k8p|1k8p]], [[2hri|2hri]], [[3qsf|3qsf]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qsc RCSB], [http://www.ebi.ac.uk/pdbsum/3qsc PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qsc RCSB], [http://www.ebi.ac.uk/pdbsum/3qsc PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 14: | ||
Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes.,Campbell NH, Karim N, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle S J Med Chem. 2011 Nov 24. PMID:22112241<ref>PMID:22112241</ref> | Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes.,Campbell NH, Karim N, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle S J Med Chem. 2011 Nov 24. PMID:22112241<ref>PMID:22112241</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 20: | Line 20: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Campbell, N H | + | [[Category: Campbell, N H]] |
| - | [[Category: Karim, N H.Abd | + | [[Category: Karim, N H.Abd]] |
| - | [[Category: Neidle, S | + | [[Category: Neidle, S]] |
| - | [[Category: Parkinson, G N | + | [[Category: Parkinson, G N]] |
| - | [[Category: Vilar, R | + | [[Category: Vilar, R]] |
[[Category: Copper complex]] | [[Category: Copper complex]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
Revision as of 21:58, 3 January 2015
The first crystal structure of a human telomeric G-quadruplex DNA bound to a metal-containing ligand (a copper complex)
| |||||||||||
Categories: Campbell, N H | Karim, N H.Abd | Neidle, S | Parkinson, G N | Vilar, R | Copper complex | Dna | Drug | Metal complex | Parallel | Quadruplex | Telomere
