2g9t
From Proteopedia
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| - | [[Image:2g9t.gif|left|200px]] | + | [[Image:2g9t.gif|left|200px]] |
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| - | '''Crystal structure of the SARS coronavirus nsp10 at 2.1A''' | + | {{Structure |
| + | |PDB= 2g9t |SIZE=350|CAPTION= <scene name='initialview01'>2g9t</scene>, resolution 2.1Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal structure of the SARS coronavirus nsp10 at 2.1A''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2G9T is a [ | + | 2G9T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9T OCA]. |
==Reference== | ==Reference== | ||
| - | Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10., Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z, J Virol. 2006 Aug;80(16):7902-8. PMID:[http:// | + | Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10., Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z, J Virol. 2006 Aug;80(16):7902-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16873247 16873247] |
[[Category: Human sars coronavirus]] | [[Category: Human sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: crystal structure]] | [[Category: crystal structure]] | ||
[[Category: nsp10]] | [[Category: nsp10]] | ||
| - | [[Category: | + | [[Category: sar]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:02:07 2008'' |
Revision as of 15:02, 20 March 2008
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| , resolution 2.1Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the SARS coronavirus nsp10 at 2.1A
Overview
The severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural proteins nsp1 to nsp16 have been implicated by genetic analysis in the assembly of a functional replication/transcription complex. We report the crystal structure of nsp10 from SARS-CoV at 2.1-A resolution. The nsp10 structure has a novel fold, and 12 identical subunits assemble to form a unique spherical dodecameric architecture. Two zinc fingers have been identified from the nsp10 monomer structure with the sequence motifs C-(X)2-C-(X)5-H-(X)6-C and C-(X)2-C-(X)7-C-(X)-C. The nsp10 crystal structure is the first of a new class of zinc finger protein three-dimensional structures to be revealed experimentally. The zinc finger sequence motifs are conserved among all three coronavirus antigenic groups, implicating an essential function for nsp10 in all coronaviruses. Based on the structure, we propose that nsp10 is a transcription factor for coronavirus replication/transcription.
About this Structure
2G9T is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10., Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z, J Virol. 2006 Aug;80(16):7902-8. PMID:16873247
Page seeded by OCA on Thu Mar 20 17:02:07 2008
Categories: Human sars coronavirus | Single protein | Lou, Z. | Rao, Z. | Su, D. | Sun, F. | Yang, H. | ZN | Crystal structure | Nsp10 | Sar
