2ga7

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[[Image:2ga7.gif|left|200px]]<br /><applet load="2ga7" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2ga7.gif|left|200px]]
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caption="2ga7" />
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'''Solution structure of the copper(I) form of the third metal-binding domain of ATP7A protein (menkes disease protein)'''<br />
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{{Structure
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|PDB= 2ga7 |SIZE=350|CAPTION= <scene name='initialview01'>2ga7</scene>
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|SITE=
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|LIGAND= <scene name='pdbligand=CU1:COPPER (I) ION'>CU1</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4]
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|GENE= ATP7A, MC1, MNK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Solution structure of the copper(I) form of the third metal-binding domain of ATP7A protein (menkes disease protein)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2GA7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CU1:'>CU1</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GA7 OCA].
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2GA7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GA7 OCA].
==Reference==
==Reference==
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Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein., Banci L, Bertini I, Cantini F, DellaMalva N, Herrmann T, Rosato A, Wuthrich K, J Biol Chem. 2006 Sep 29;281(39):29141-7. Epub 2006 Jul 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16873374 16873374]
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Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein., Banci L, Bertini I, Cantini F, DellaMalva N, Herrmann T, Rosato A, Wuthrich K, J Biol Chem. 2006 Sep 29;281(39):29141-7. Epub 2006 Jul 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16873374 16873374]
[[Category: Copper-exporting ATPase]]
[[Category: Copper-exporting ATPase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: solution structure]]
[[Category: solution structure]]
[[Category: spine]]
[[Category: spine]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: structural proteomics in europe]]
[[Category: structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:02:14 2008''

Revision as of 15:02, 20 March 2008

Image:2ga7.gif


PDB ID 2ga7

Drag the structure with the mouse to rotate
Ligands:
Gene: ATP7A, MC1, MNK (Homo sapiens)
Activity: Copper-exporting ATPase, with EC number 3.6.3.4
Coordinates: save as pdb, mmCIF, xml



Solution structure of the copper(I) form of the third metal-binding domain of ATP7A protein (menkes disease protein)


Contents

Overview

The third metal-binding domain of the human Menkes protein (MNK3), a copper(I)-transporting ATPase, has been expressed in Escherichia coli and characterized in solution. The solution structure of MNK3, its copper(I)-binding properties, and its interaction with the physiological partner, HAH1, have been studied. MNK3 is the domain most dissimilar in structure from the other domains of the Menkes protein. This is reflected in a significant rearrangement of the last strand of the four-stranded beta-sheet when compared with the other known homologous proteins or protein domains. MNK3 is also peculiar with respect to its interaction with the copper(I) ion, as it was found to be a comparatively weak binder. Copper(I) transfer from metal-loaded HAH1 was observed experimentally, but the metal distribution was shifted toward binding by HAH1. This is at variance with what is observed for the other Menkes domains.

Disease

Known diseases associated with this structure: Analgesia from kappa-opioid receptor agonist, female-specific , OMIM:[155555], Cutis laxa, neonatal OMIM:[300011], Melanoma susceptibility to OMIM:[155555], Menkes disease OMIM:[300011], Occipital horn syndrome OMIM:[300011], Oculocutaneous albinism, type II, modifier of OMIM:[155555], Skin/hair/eye pigmentation 2, blond hair/fair skin OMIM:[155555], Skin/hair/eye pigmentation 2, red hair/fair skin OMIM:[155555], UV-induced skin damage OMIM:[155555]

About this Structure

2GA7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein., Banci L, Bertini I, Cantini F, DellaMalva N, Herrmann T, Rosato A, Wuthrich K, J Biol Chem. 2006 Sep 29;281(39):29141-7. Epub 2006 Jul 26. PMID:16873374

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