2gcu

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[[Image:2gcu.gif|left|200px]]<br /><applet load="2gcu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2gcu.gif|left|200px]]
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caption="2gcu, resolution 1.477&Aring;" />
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'''X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580'''<br />
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{{Structure
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|PDB= 2gcu |SIZE=350|CAPTION= <scene name='initialview01'>2gcu</scene>, resolution 1.477&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Hydroxyacylglutathione_hydrolase Hydroxyacylglutathione hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.6 3.1.2.6]
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|GENE= At1g53580 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])
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}}
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'''X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2GCU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with <scene name='pdbligand=FE2:'>FE2</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hydroxyacylglutathione_hydrolase Hydroxyacylglutathione hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.6 3.1.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCU OCA].
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2GCU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCU OCA].
==Reference==
==Reference==
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Structure of an ETHE1-like protein from Arabidopsis thaliana., McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN Jr, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):964-70. Epub 2006, Aug 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16929096 16929096]
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Structure of an ETHE1-like protein from Arabidopsis thaliana., McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN Jr, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):964-70. Epub 2006, Aug 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16929096 16929096]
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Hydroxyacylglutathione hydrolase]]
[[Category: Hydroxyacylglutathione hydrolase]]
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[[Category: FE2]]
[[Category: FE2]]
[[Category: SO4]]
[[Category: SO4]]
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[[Category: center for eukaryotic structural genomics]]
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[[Category: center for eukaryotic structural genomic]]
[[Category: cesg]]
[[Category: cesg]]
[[Category: ethe1]]
[[Category: ethe1]]
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[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:30:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:03:12 2008''

Revision as of 15:03, 20 March 2008

Image:2gcu.gif


PDB ID 2gcu

Drag the structure with the mouse to rotate
, resolution 1.477Å
Ligands: , and
Gene: At1g53580 (Arabidopsis thaliana)
Activity: Hydroxyacylglutathione hydrolase, with EC number 3.1.2.6
Coordinates: save as pdb, mmCIF, xml



X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580


Overview

The protein product of gene At1g53580 from Arabidopsis thaliana possesses 54% sequence identity to a human enzyme that has been implicated in the rare disorder ethylmalonic encephalopathy. The structure of the At1g53580 protein has been solved to a nominal resolution of 1.48 Angstrom. This structure reveals tertiary structure differences between the ETHE1-like enzyme and glyoxalase II enzymes that are likely to account for differences in reaction chemistry and multimeric state between the two types of enzymes. In addition, the Arabidopsis ETHE1 protein is used as a model to explain the significance of several mutations in the human enzyme that have been observed in patients with ethylmalonic encephalopathy.

About this Structure

2GCU is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Structure of an ETHE1-like protein from Arabidopsis thaliana., McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN Jr, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):964-70. Epub 2006, Aug 19. PMID:16929096

Page seeded by OCA on Thu Mar 20 17:03:12 2008

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