2gcz
From Proteopedia
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| - | [[Image:2gcz.gif|left|200px]] | + | [[Image:2gcz.gif|left|200px]] |
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| - | '''Solution Structure of alpha-Conotoxin OmIA''' | + | {{Structure |
| + | |PDB= 2gcz |SIZE=350|CAPTION= <scene name='initialview01'>2gcz</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Solution Structure of alpha-Conotoxin OmIA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2GCZ is a [ | + | 2GCZ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCZ OCA]. |
==Reference== | ==Reference== | ||
| - | Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2006 Jun 23;345(1):248-54. Epub 2006 Apr 27. PMID:[http:// | + | Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2006 Jun 23;345(1):248-54. Epub 2006 Apr 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16678128 16678128] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Chi, S W.]] | [[Category: Chi, S W.]] | ||
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[[Category: beta-turn]] | [[Category: beta-turn]] | ||
[[Category: c-terminal amidation]] | [[Category: c-terminal amidation]] | ||
| - | [[Category: two disulfide | + | [[Category: two disulfide bond]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:03:15 2008'' |
Revision as of 15:03, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of alpha-Conotoxin OmIA
Overview
alpha-Conotoxin OmIA from Conus omaria is the only alpha-conotoxin that shows a approximately 20-fold higher affinity to the alpha3beta2 over the alpha6beta2 subtype of nicotinic acetylcholine receptor. We have determined a three-dimensional structure of alpha-conotoxin OmIA by nuclear magnetic resonance spectroscopy. alpha-Conotoxin OmIA has an "omega-shaped" overall topology with His(5)-Asn(12) forming an alpha-helix. Structural features of alpha-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related alpha4/7 subfamily conotoxins. Reduced size of the hydrophilic area in alpha-conotoxin OmIA seems to be associated with the reduced affinity towards the alpha6beta2 nAChR subtype.
About this Structure
2GCZ is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2006 Jun 23;345(1):248-54. Epub 2006 Apr 27. PMID:16678128
Page seeded by OCA on Thu Mar 20 17:03:15 2008
