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3our
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of complex between EIIA and a novel pyruvate decarboxylase== | |
| - | + | <StructureSection load='3our' size='340' side='right' caption='[[3our]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3our]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_vulnificus_cmcp6 Vibrio vulnificus cmcp6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUR FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VV1_0328 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216895 Vibrio vulnificus CMCP6]), VV1_0212 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216895 Vibrio vulnificus CMCP6])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3our FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3our OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3our RCSB], [http://www.ebi.ac.uk/pdbsum/3our PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The interaction between fermentation-respiration switch (FrsA) protein and glucose-specific enzyme IIA(Glc) increases glucose fermentation under oxygen-limited conditions. We show that FrsA converts pyruvate to acetaldehyde and carbon dioxide in a cofactor-independent manner and that its pyruvate decarboxylation activity is enhanced by the dephosphorylated form of IIA(Glc) (d-IIA(Glc)). Crystal structures of FrsA and its complex with d-IIA(Glc) revealed residues required for catalysis as well as the structural basis for the activation by d-IIA(Glc). | ||
| - | + | FrsA functions as a cofactor-independent decarboxylase to control metabolic flux.,Lee KJ, Jeong CS, An YJ, Lee HJ, Park SJ, Seok YJ, Kim P, Lee JH, Lee KH, Cha SS Nat Chem Biol. 2011 May 29. PMID:21623357<ref>PMID:21623357</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Phosphotransferase|Phosphotransferase]] | *[[Phosphotransferase|Phosphotransferase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Vibrio vulnificus cmcp6]] | [[Category: Vibrio vulnificus cmcp6]] | ||
| - | [[Category: An, Y J | + | [[Category: An, Y J]] |
| - | [[Category: Cha, S S | + | [[Category: Cha, S S]] |
| - | [[Category: Jeong, C S | + | [[Category: Jeong, C S]] |
[[Category: Exhibit no hydrolase activity1]] | [[Category: Exhibit no hydrolase activity1]] | ||
[[Category: Lyase-transferase complex]] | [[Category: Lyase-transferase complex]] | ||
Revision as of 22:45, 3 January 2015
Crystal structure of complex between EIIA and a novel pyruvate decarboxylase
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