This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2x81
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
<StructureSection load='2x81' size='340' side='right' caption='[[2x81]], [[Resolution|resolution]] 2.91Å' scene=''> | <StructureSection load='2x81' size='340' side='right' caption='[[2x81]], [[Resolution|resolution]] 2.91Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2x81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X81 OCA]. <br> | + | <table><tr><td colspan='2'>[[2x81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X81 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZZL:4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC+ACID'>ZZL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZZL:4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC+ACID'>ZZL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1muo|1muo]], [[2x6d|2x6d]], [[2j50|2j50]], [[2w1d|2w1d]], [[1ol6|1ol6]], [[2bmc|2bmc]], [[2c6e|2c6e]], [[2j4z|2j4z]], [[1ol5|1ol5]], [[2c6d|2c6d]], [[2wtw|2wtw]], [[2wqe|2wqe]], [[2w1c|2w1c]], [[2w1g|2w1g]], [[2wtv|2wtv]], [[1ol7|1ol7]], [[2w1e|2w1e]], [[2w1f|2w1f]], [[1mq4|1mq4]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1muo|1muo]], [[2x6d|2x6d]], [[2j50|2j50]], [[2w1d|2w1d]], [[1ol6|1ol6]], [[2bmc|2bmc]], [[2c6e|2c6e]], [[2j4z|2j4z]], [[1ol5|1ol5]], [[2c6d|2c6d]], [[2wtw|2wtw]], [[2wqe|2wqe]], [[2w1c|2w1c]], [[2w1g|2w1g]], [[2wtv|2wtv]], [[1ol7|1ol7]], [[2w1e|2w1e]], [[2w1f|2w1f]], [[1mq4|1mq4]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x81 RCSB], [http://www.ebi.ac.uk/pdbsum/2x81 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x81 RCSB], [http://www.ebi.ac.uk/pdbsum/2x81 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 24: | ||
Drug-resistant Aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237.,Sloane D, Trikic M, Chu ML, Lamers M, Mason C, Mueller I, Savory W, Williams DH, Eyers PA ACS Chem Biol. 2010 Apr 28. PMID:20426425<ref>PMID:20426425</ref> | Drug-resistant Aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237.,Sloane D, Trikic M, Chu ML, Lamers M, Mason C, Mueller I, Savory W, Williams DH, Eyers PA ACS Chem Biol. 2010 Apr 28. PMID:20426425<ref>PMID:20426425</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 32: | Line 35: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| - | [[Category: Eyers, P A | + | [[Category: Eyers, P A]] |
| - | [[Category: Lamers, M | + | [[Category: Lamers, M]] |
| - | [[Category: Mason, C S | + | [[Category: Mason, C S]] |
| - | [[Category: Mueller, I | + | [[Category: Mueller, I]] |
| - | [[Category: Savory, W | + | [[Category: Savory, W]] |
| - | [[Category: Williams, D H | + | [[Category: Williams, D H]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cytoskeleton]] | [[Category: Cytoskeleton]] | ||
[[Category: Drug-resistance]] | [[Category: Drug-resistance]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 22:49, 3 January 2015
STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054
| |||||||||||
