3p4j

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{{STRUCTURE_3p4j| PDB=3p4j | SCENE= }}
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==Ultra-high resolution structure of d(CGCGCG)2 Z-DNA==
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===Ultra-high resolution structure of d(CGCGCG)2 Z-DNA===
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<StructureSection load='3p4j' size='340' side='right' caption='[[3p4j]], [[Resolution|resolution]] 0.55&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21459852}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3p4j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P4J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d48|1d48]], [[1dcg|1dcg]], [[2dcg|2dcg]], [[1i0t|1i0t]], [[1ick|1ick]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4j RCSB], [http://www.ebi.ac.uk/pdbsum/3p4j PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a Z-DNA hexamer duplex d(CGCGCG)(2) determined at ultra high resolution of 0.55 A and refined without restraints, displays a high degree of regularity and rigidity in its stereochemistry, in contrast to the more flexible B-DNA duplexes. The estimations of standard uncertainties of all individually refined parameters, obtained by full-matrix least-squares optimization, are comparable with values that are typical for small-molecule crystallography. The Z-DNA model generated with ultra high-resolution diffraction data can be used to revise the stereochemical restraints applied in lower resolution refinements. Detailed comparisons of the stereochemical library values with the present accurate Z-DNA parameters, shows in general a good agreement, but also reveals significant discrepancies in the description of guanine-sugar valence angles and in the geometry of the phosphate groups.
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==About this Structure==
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High regularity of Z-DNA revealed by ultra high-resolution crystal structure at 0.55 A.,Brzezinski K, Brzuszkiewicz A, Dauter M, Kubicki M, Jaskolski M, Dauter Z Nucleic Acids Res. 2011 Aug 1;39(14):6238-48. Epub 2011 Apr 1. PMID:21459852<ref>PMID:21459852</ref>
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[[3p4j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4J OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:021459852</ref><references group="xtra"/><references/>
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</div>
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[[Category: Brzezinski, K.]]
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== References ==
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[[Category: Brzuszkiewicz, A.]]
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<references/>
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[[Category: Dauter, M.]]
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__TOC__
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[[Category: Dauter, Z.]]
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</StructureSection>
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[[Category: Jaskolski, M.]]
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[[Category: Brzezinski, K]]
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[[Category: Kubicki, M.]]
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[[Category: Brzuszkiewicz, A]]
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[[Category: Dauter, M]]
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[[Category: Dauter, Z]]
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[[Category: Jaskolski, M]]
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[[Category: Kubicki, M]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Z-dna]]
[[Category: Z-dna]]

Revision as of 22:56, 3 January 2015

Ultra-high resolution structure of d(CGCGCG)2 Z-DNA

3p4j, resolution 0.55Å

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