3op5

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3op5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OP5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3op5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OP5 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=REB:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE'>REB</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=REB:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE'>REB</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3op5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3op5 RCSB], [http://www.ebi.ac.uk/pdbsum/3op5 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3op5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3op5 RCSB], [http://www.ebi.ac.uk/pdbsum/3op5 PDBsum]</span></td></tr>
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<table>
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</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Allerston, C K.]]
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[[Category: Allerston, C K]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Berridge, G.]]
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[[Category: Berridge, G]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Brenner, B.]]
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[[Category: Brenner, B]]
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[[Category: Chalk, R.]]
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[[Category: Chalk, R]]
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[[Category: Das, S.]]
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[[Category: Das, S]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins, J M]]
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[[Category: Eswaran, J.]]
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[[Category: Eswaran, J]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov, O]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos, P]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi, O]]
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[[Category: Keates, T.]]
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[[Category: Keates, T]]
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[[Category: King, O.]]
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[[Category: King, O]]
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[[Category: Knapp, S.]]
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[[Category: Knapp, S]]
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[[Category: Krojer, T.]]
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[[Category: Krojer, T]]
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[[Category: Rellos, P.]]
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[[Category: Rellos, P]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Savitsky, P.]]
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[[Category: Savitsky, P]]
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[[Category: Uttarkar, S.]]
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[[Category: Uttarkar, S]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Adenosine triphosphate]]
[[Category: Adenosine triphosphate]]
[[Category: Amino acid sequence]]
[[Category: Amino acid sequence]]
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[[Category: Protein folding]]
[[Category: Protein folding]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Surface entropy reduction]]
[[Category: Surface entropy reduction]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 23:09, 3 January 2015

Human vaccinia-related kinase 1

3op5, resolution 2.40Å

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