2mgy
From Proteopedia
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| - | + | ==Solution structure of the mitochondrial translocator protein (TSPO) in complex with its high-affinity ligand PK11195== | |
| - | + | <StructureSection load='2mgy' size='340' side='right' caption='[[2mgy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2mgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MGY FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PKA:N-[(2R)-BUTAN-2-YL]-1-(2-CHLOROPHENYL)-N-METHYLISOQUINOLINE-3-CARBOXAMIDE'>PKA</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tspo, Bzrp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mgy RCSB], [http://www.ebi.ac.uk/pdbsum/2mgy PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The 18-kilodalton translocator protein TSPO is found in mitochondrial membranes and mediates the import of cholesterol and porphyrins into mitochondria. In line with the role of TSPO in mitochondrial function, TSPO ligands are used for a variety of diagnostic and therapeutic applications in animals and humans. We present the three-dimensional high-resolution structure of mammalian TSPO reconstituted in detergent micelles in complex with its high-affinity ligand PK11195. The TSPO-PK11195 structure is described by a tight bundle of five transmembrane alpha helices that form a hydrophobic pocket accepting PK11195. Ligand-induced stabilization of the structure of TSPO suggests a molecular mechanism for the stimulation of cholesterol transport into mitochondria. | ||
| - | + | Structure of the mitochondrial translocator protein in complex with a diagnostic ligand.,Jaremko L, Jaremko M, Giller K, Becker S, Zweckstetter M Science. 2014 Mar 21;343(6177):1363-6. doi: 10.1126/science.1248725. PMID:24653034<ref>PMID:24653034</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Becker, S | + | == References == |
| - | [[Category: Giller, K | + | <references/> |
| - | [[Category: Jaremko, L | + | __TOC__ |
| - | [[Category: Jaremko, M | + | </StructureSection> |
| - | [[Category: Zweckstetter, M | + | [[Category: Lk3 transgenic mice]] |
| + | [[Category: Becker, S]] | ||
| + | [[Category: Giller, K]] | ||
| + | [[Category: Jaremko, L]] | ||
| + | [[Category: Jaremko, M]] | ||
| + | [[Category: Zweckstetter, M]] | ||
[[Category: Dpc micelle]] | [[Category: Dpc micelle]] | ||
[[Category: Helical membrane channel protein]] | [[Category: Helical membrane channel protein]] | ||
Revision as of 23:12, 3 January 2015
Solution structure of the mitochondrial translocator protein (TSPO) in complex with its high-affinity ligand PK11195
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