3zdr
From Proteopedia
(Difference between revisions)
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| - | + | ==Structure of the Alcohol dehydrogenase (ADH) domain of a bifunctional ADHE dehydrogenase from Geobacillus thermoglucosidasius NCIMB 11955== | |
| - | + | <StructureSection load='3zdr' size='340' side='right' caption='[[3zdr]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3zdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoglucosidasius Geobacillus thermoglucosidasius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZDR FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zdr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zdr RCSB], [http://www.ebi.ac.uk/pdbsum/3zdr PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bifunctional alcohol/aldehyde dehydrogenase (ADHE) enzymes are found within many fermentative microorganisms. They catalyse the conversion of an acyl-coenzyme A to an alcohol via an aldehyde intermediate; this is coupled to the oxidation of two NADH molecules to maintain the NAD+ pool during fermentative metabolism. The structure of the alcohol dehydrogenase (ADH) domain of an ADHE protein from the ethanol-producing thermophile Geobacillus thermoglucosidasius has been determined to 2.5 A resolution. This is the first structure to be reported for such a domain. In silico modelling has been carried out to generate a homology model of the aldehyde dehydrogenase domain, and this was subsequently docked with the ADH-domain structure to model the structure of the complete ADHE protein. This model suggests, for the first time, a structural mechanism for the formation of the large multimeric assemblies or `spirosomes' that are observed for this ADHE protein and which have previously been reported for ADHEs from other organisms. | ||
| - | + | Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius.,Extance J, Crennell SJ, Eley K, Cripps R, Hough DW, Danson MJ Acta Crystallogr D Biol Crystallogr. 2013 Oct 1;69(Pt 10):2104-2115. Epub 2013, Sep 20. PMID:24100328<ref>PMID:24100328</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Geobacillus thermoglucosidasius]] | [[Category: Geobacillus thermoglucosidasius]] | ||
| - | [[Category: Crennell, S J | + | [[Category: Crennell, S J]] |
| - | [[Category: Cripps, R | + | [[Category: Cripps, R]] |
| - | [[Category: Danson, M J | + | [[Category: Danson, M J]] |
| - | [[Category: Eley, K | + | [[Category: Eley, K]] |
| - | [[Category: Extance, J | + | [[Category: Extance, J]] |
| - | [[Category: Hough, D W | + | [[Category: Hough, D W]] |
[[Category: Bifunctional alcohol/aldehyde dehydrogenase]] | [[Category: Bifunctional alcohol/aldehyde dehydrogenase]] | ||
[[Category: Bioethanol]] | [[Category: Bioethanol]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 09:18, 4 January 2015
Structure of the Alcohol dehydrogenase (ADH) domain of a bifunctional ADHE dehydrogenase from Geobacillus thermoglucosidasius NCIMB 11955
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