3zsv
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zsv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZSV FirstGlance]. <br> | <table><tr><td colspan='2'>[[3zsv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZSV FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZSV:(R)-[(2S)-5-CARBOXY-2-(2-CARBOXYETHYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL]METHYL-[[2-[(4-METHOXYPHENYL)METHYLCARBAMOYL]PHENYL]METHYL]-PROP-2-ENYL-AZANIUM'>ZSV</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZSV:(R)-[(2S)-5-CARBOXY-2-(2-CARBOXYETHYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL]METHYL-[[2-[(4-METHOXYPHENYL)METHYLCARBAMOYL]PHENYL]METHYL]-PROP-2-ENYL-AZANIUM'>ZSV</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zsq|3zsq]], [[3zt2|3zt2]], [[3zt3|3zt3]], [[3zt4|3zt4]], [[3zsw|3zsw]], [[1hyz|1hyz]], [[3zt1|3zt1]], [[3zso|3zso]], [[1hyv|1hyv]], [[3zsx|3zsx]], [[3zsz|3zsz]], [[3zt0|3zt0]], [[3zsy|3zsy]], [[3zsr|3zsr]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zsq|3zsq]], [[3zt2|3zt2]], [[3zt3|3zt3]], [[3zt4|3zt4]], [[3zsw|3zsw]], [[1hyz|1hyz]], [[3zt1|3zt1]], [[3zso|3zso]], [[1hyv|1hyv]], [[3zsx|3zsx]], [[3zsz|3zsz]], [[3zt0|3zt0]], [[3zsy|3zsy]], [[3zsr|3zsr]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zsv RCSB], [http://www.ebi.ac.uk/pdbsum/3zsv PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zsv RCSB], [http://www.ebi.ac.uk/pdbsum/3zsv PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 13: | Line 13: | ||
Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design.,Peat TS, Rhodes DI, Vandegraaff N, Le G, Smith JA, Clark LJ, Jones ED, Coates JA, Thienthong N, Newman J, Dolezal O, Mulder R, Ryan JH, Savage GP, Francis CL, Deadman JJ PLoS One. 2012;7(7):e40147. Epub 2012 Jul 10. PMID:22808106<ref>PMID:22808106</ref> | Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design.,Peat TS, Rhodes DI, Vandegraaff N, Le G, Smith JA, Clark LJ, Jones ED, Coates JA, Thienthong N, Newman J, Dolezal O, Mulder R, Ryan JH, Savage GP, Francis CL, Deadman JJ PLoS One. 2012;7(7):e40147. Epub 2012 Jul 10. PMID:22808106<ref>PMID:22808106</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 20: | Line 20: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human immunodeficiency virus]] | [[Category: Human immunodeficiency virus]] | ||
| - | [[Category: Coates, J A.V | + | [[Category: Coates, J A.V]] |
| - | [[Category: Deadman, J J | + | [[Category: Deadman, J J]] |
| - | [[Category: Dolezal, O | + | [[Category: Dolezal, O]] |
| - | [[Category: Francis, C L | + | [[Category: Francis, C L]] |
| - | [[Category: Jones, E D | + | [[Category: Jones, E D]] |
| - | [[Category: Le, G | + | [[Category: Le, G]] |
| - | [[Category: Newman, J | + | [[Category: Newman, J]] |
| - | [[Category: Peat, T S | + | [[Category: Peat, T S]] |
| - | [[Category: Rhodes, D I | + | [[Category: Rhodes, D I]] |
| - | [[Category: Ryan, J H | + | [[Category: Ryan, J H]] |
| - | [[Category: Savage, G P | + | [[Category: Savage, G P]] |
| - | [[Category: Smith, J A | + | [[Category: Smith, J A]] |
| - | [[Category: Thienthong, N | + | [[Category: Thienthong, N]] |
| - | [[Category: Vandergraaff, N | + | [[Category: Vandergraaff, N]] |
[[Category: Aid]] | [[Category: Aid]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 09:19, 4 January 2015
Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
| |||||||||||
