2gj7
From Proteopedia
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| - | [[Image:2gj7.gif|left|200px]] | + | [[Image:2gj7.gif|left|200px]] |
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| - | '''Crystal Structure of a gE-gI/Fc complex''' | + | {{Structure |
| + | |PDB= 2gj7 |SIZE=350|CAPTION= <scene name='initialview01'>2gj7</scene>, resolution 5.Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= IgG1 heavy chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), GE, US8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 Human herpesvirus 4]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of a gE-gI/Fc complex''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2GJ7 is a [ | + | 2GJ7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJ7 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging., Sprague ER, Wang C, Baker D, Bjorkman PJ, PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:[http:// | + | Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging., Sprague ER, Wang C, Baker D, Bjorkman PJ, PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16646632 16646632] |
[[Category: Cricetulus griseus]] | [[Category: Cricetulus griseus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: low resolution]] | [[Category: low resolution]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:05:19 2008'' |
Revision as of 15:05, 20 March 2008
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| , resolution 5.Å | |||||||
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| Gene: | IgG1 heavy chain (Homo sapiens), GE, US8 (Human herpesvirus 4) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of a gE-gI/Fc complex
Overview
Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the cell-to-cell spread of virus. gE-gI binds immunoglobulin G at the basic pH of the cell surface and releases it at the acidic pH of lysosomes, consistent with a role in facilitating the degradation of antiviral antibodies. Here we identify the C-terminal domain of the gE ectodomain (CgE) as the minimal Fc-binding domain and present a 1.78-angstroms CgE structure. A 5-angstroms gE-gI/Fc crystal structure, which was independently verified by a theoretical prediction method, reveals that CgE binds Fc at the C(H)2-C(H)3 interface, the binding site for several mammalian and bacterial Fc-binding proteins. The structure identifies interface histidines that may confer pH-dependent binding and regions of CgE implicated in cell-to-cell spread of virus. The ternary organization of the gE-gI/Fc complex is compatible with antibody bipolar bridging, which can interfere with the antiviral immune response.
About this Structure
2GJ7 is a Protein complex structure of sequences from Cricetulus griseus, Homo sapiens and Human herpesvirus 4. Full crystallographic information is available from OCA.
Reference
Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging., Sprague ER, Wang C, Baker D, Bjorkman PJ, PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:16646632
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