3w8o
From Proteopedia
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| - | + | ==Crystal Structure of HasAp with Iron Phthalocyanine== | |
| - | + | <StructureSection load='3w8o' size='340' side='right' caption='[[3w8o]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3w8o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W8O FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WPC:[29H,31H-PHTHALOCYANINATO(2-)-KAPPA~4~N~29~,N~30~,N~31~,N~32~]IRON'>WPC</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w8m|3w8m]], [[3wah|3wah]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hasAp, PA3407 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w8o RCSB], [http://www.ebi.ac.uk/pdbsum/3w8o PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasAp ) can capture several synthetic metal complexes other than heme. The crystal structures of HasAp harboring synthetic metal complexes revealed only small perturbation of the overall HasAp structure. An inhibitory effect upon heme acquisition by HasAp bearing synthetic metal complexes was examined by monitoring the growth of Pseudomonas aeruginosa PAO1. HasAp bound to iron-phthalocyanine inhibits heme acquisition in the presence of heme-bound HasAp as an iron source. | ||
| - | + | Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp ) Bound to Synthetic Metal Complexes.,Shirataki C, Shoji O, Terada M, Ozaki S, Sugimoto H, Shiro Y, Watanabe Y Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2862-6. doi: 10.1002/anie.201307889., Epub 2014 Feb 7. PMID:24604808<ref>PMID:24604808</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Shirataki, C | + | == References == |
| - | [[Category: Shiro, Y | + | <references/> |
| - | [[Category: Shoji, O | + | __TOC__ |
| - | [[Category: Sugimoto, H | + | </StructureSection> |
| - | [[Category: Terada, M | + | [[Category: Pseae]] |
| - | [[Category: Watanabe, Y | + | [[Category: Shirataki, C]] |
| + | [[Category: Shiro, Y]] | ||
| + | [[Category: Shoji, O]] | ||
| + | [[Category: Sugimoto, H]] | ||
| + | [[Category: Terada, M]] | ||
| + | [[Category: Watanabe, Y]] | ||
[[Category: Heme binding protein]] | [[Category: Heme binding protein]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 09:25, 4 January 2015
Crystal Structure of HasAp with Iron Phthalocyanine
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