This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3w7r
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097== | |
| - | + | <StructureSection load='3w7r' size='340' side='right' caption='[[3w7r]], [[Resolution|resolution]] 1.68Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[3w7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W7R FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DDQ:DECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DDQ</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W7A:2,6-DIOXO-5-[2-(4-PHENYLPHENYL)ETHYL]-1,2,3,6-+TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7A</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w71|3w71]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w7r RCSB], [http://www.ebi.ac.uk/pdbsum/3w7r PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | [[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | ||
| - | + | == Function == | |
| - | ==Function== | + | |
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | [[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Human]] | |
| - | <references | + | [[Category: Aoki, T]] |
| - | [[Category: Aoki, T | + | [[Category: Balogun, E O]] |
| - | [[Category: Balogun, E O | + | [[Category: Harada, S]] |
| - | [[Category: Harada, S | + | [[Category: Hashimoto, S]] |
| - | [[Category: Hashimoto, S | + | [[Category: Honma, T]] |
| - | [[Category: Honma, T | + | [[Category: Iida, M]] |
| - | [[Category: Iida, M | + | [[Category: Inaoka, D K]] |
| - | [[Category: Inaoka, D K | + | [[Category: Inoue, M]] |
| - | [[Category: Inoue, M | + | [[Category: Kita, K]] |
| - | [[Category: Kita, K | + | [[Category: Kuranaga, T]] |
| - | [[Category: Kuranaga, T | + | [[Category: Lee, N]] |
| - | [[Category: Lee, N | + | [[Category: Matsuoka, S]] |
| - | [[Category: Matsuoka, S | + | [[Category: Nara, T]] |
| - | [[Category: Nara, T | + | [[Category: Sakamoto, K]] |
| - | [[Category: Sakamoto, K | + | [[Category: Shiba, T]] |
| - | [[Category: Shiba, T | + | [[Category: Suzuki, S]] |
| - | [[Category: Suzuki, S | + | [[Category: Tabuchi, T]] |
| - | [[Category: Tabuchi, T | + | [[Category: Tanaka, A]] |
| - | [[Category: Tanaka, A | + | |
[[Category: Dihydroorotate/orotate and ubiquinone/ubiquinol]] | [[Category: Dihydroorotate/orotate and ubiquinone/ubiquinol]] | ||
[[Category: Mitochondrial inner membrane]] | [[Category: Mitochondrial inner membrane]] | ||
Revision as of 09:32, 4 January 2015
Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097
| |||||||||||
Categories: Human | Aoki, T | Balogun, E O | Harada, S | Hashimoto, S | Honma, T | Iida, M | Inaoka, D K | Inoue, M | Kita, K | Kuranaga, T | Lee, N | Matsuoka, S | Nara, T | Sakamoto, K | Shiba, T | Suzuki, S | Tabuchi, T | Tanaka, A | Dihydroorotate/orotate and ubiquinone/ubiquinol | Mitochondrial inner membrane | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex | Rossmann fold
