3w7r
From Proteopedia
(Difference between revisions)
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| - | + | ==Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097== | |
| - | + | <StructureSection load='3w7r' size='340' side='right' caption='[[3w7r]], [[Resolution|resolution]] 1.68Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[3w7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W7R FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DDQ:DECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DDQ</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W7A:2,6-DIOXO-5-[2-(4-PHENYLPHENYL)ETHYL]-1,2,3,6-+TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7A</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w71|3w71]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w7r RCSB], [http://www.ebi.ac.uk/pdbsum/3w7r PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | [[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | ||
| - | + | == Function == | |
| - | ==Function== | + | |
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | [[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Human]] | |
| - | <references | + | [[Category: Aoki, T]] |
| - | [[Category: Aoki, T | + | [[Category: Balogun, E O]] |
| - | [[Category: Balogun, E O | + | [[Category: Harada, S]] |
| - | [[Category: Harada, S | + | [[Category: Hashimoto, S]] |
| - | [[Category: Hashimoto, S | + | [[Category: Honma, T]] |
| - | [[Category: Honma, T | + | [[Category: Iida, M]] |
| - | [[Category: Iida, M | + | [[Category: Inaoka, D K]] |
| - | [[Category: Inaoka, D K | + | [[Category: Inoue, M]] |
| - | [[Category: Inoue, M | + | [[Category: Kita, K]] |
| - | [[Category: Kita, K | + | [[Category: Kuranaga, T]] |
| - | [[Category: Kuranaga, T | + | [[Category: Lee, N]] |
| - | [[Category: Lee, N | + | [[Category: Matsuoka, S]] |
| - | [[Category: Matsuoka, S | + | [[Category: Nara, T]] |
| - | [[Category: Nara, T | + | [[Category: Sakamoto, K]] |
| - | [[Category: Sakamoto, K | + | [[Category: Shiba, T]] |
| - | [[Category: Shiba, T | + | [[Category: Suzuki, S]] |
| - | [[Category: Suzuki, S | + | [[Category: Tabuchi, T]] |
| - | [[Category: Tabuchi, T | + | [[Category: Tanaka, A]] |
| - | [[Category: Tanaka, A | + | |
[[Category: Dihydroorotate/orotate and ubiquinone/ubiquinol]] | [[Category: Dihydroorotate/orotate and ubiquinone/ubiquinol]] | ||
[[Category: Mitochondrial inner membrane]] | [[Category: Mitochondrial inner membrane]] | ||
Revision as of 09:32, 4 January 2015
Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097
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Categories: Human | Aoki, T | Balogun, E O | Harada, S | Hashimoto, S | Honma, T | Iida, M | Inaoka, D K | Inoue, M | Kita, K | Kuranaga, T | Lee, N | Matsuoka, S | Nara, T | Sakamoto, K | Shiba, T | Suzuki, S | Tabuchi, T | Tanaka, A | Dihydroorotate/orotate and ubiquinone/ubiquinol | Mitochondrial inner membrane | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex | Rossmann fold
