3ztb

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[[Image:3ztb.png|left|200px]]
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==The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling==
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<StructureSection load='3ztb' size='340' side='right' caption='[[3ztb]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ztb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vy9|2vy9]], [[3zta|3zta]], [[3zt9|3zt9]], [[3zxn|3zxn]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ztb RCSB], [http://www.ebi.ac.uk/pdbsum/3ztb PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The stressosome complex regulates downstream effectors in response to environmental signals. In Bacillus subtilis, it activates the alternative sigma factor sigma(B), leading to the upregulation of the general stress regulon. Herein, we characterize a stressosome-regulated biochemical pathway in Moorella thermoacetica. We show that the presumed sensor, MtR, and the scaffold, MtS, form a pseudo-icosahedral structure like that observed in B. subtilis. The N-terminal domain of MtR is structurally homologous to B. subtilis RsbR, despite low sequence identity. The affinity of the switch kinase, MtT, for MtS decreases following MtS phosphorylation and not because of structural reorganization. Dephosphorylation of MtS by the PP2C type phosphatase MtX permits the switch kinase to rebind the stressosome to reset the response. We also show that MtT regulates cyclic di-GMP biosynthesis through inhibition of a GG(D/E)EF-type diguanylate cyclase, demonstrating that secondary messenger levels are regulated by the stressosome.
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The Bacterial Stressosome: A Modular System that Has Been Adapted to Control Secondary Messenger Signaling.,Quin MB, Berrisford JM, Newman JA, Basle A, Lewis RJ, Marles-Wright J Structure. 2012 Feb 8;20(2):350-63. PMID:22325782<ref>PMID:22325782</ref>
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The line below this paragraph, containing "STRUCTURE_3ztb", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3ztb| PDB=3ztb | SCENE= }}
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===The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22325782}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22325782 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22325782}}
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==About this Structure==
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[[3ztb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTB OCA].
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==Reference==
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<ref group="xtra">PMID:022325782</ref><references group="xtra"/>
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[[Category: Moorella thermoacetica]]
[[Category: Moorella thermoacetica]]
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[[Category: Basle, A.]]
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[[Category: Basle, A]]
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[[Category: Berrisford, J M.]]
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[[Category: Berrisford, J M]]
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[[Category: Lewis, R J.]]
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[[Category: Lewis, R J]]
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[[Category: Marles-Wright, J.]]
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[[Category: Marles-Wright, J]]
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[[Category: Newman, J A.]]
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[[Category: Newman, J A]]
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[[Category: Quin, M B.]]
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[[Category: Quin, M B]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]

Revision as of 09:40, 4 January 2015

The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling

3ztb, resolution 2.80Å

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