3tc2
From Proteopedia
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| - | + | ==Crystal structure of potato serine protease inhibitor.== | |
| - | === | + | <StructureSection load='3tc2' size='340' side='right' caption='[[3tc2]], [[Resolution|resolution]] 1.60Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3tc2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Solanum_tuberosum Solanum tuberosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TC2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tc2 RCSB], [http://www.ebi.ac.uk/pdbsum/3tc2 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Potato serine protease inhibitor (PSPI) constitutes about 22% of the total amount of proteins in potato tubers (cv. Elkana), making it the most abundant protease inhibitor in the plant. PSPI is a heterodimeric double-headed Kunitz-type serine protease inhibitor that can tightly and simultaneously bind two serine proteases by mimicking the substrate of the enzyme with its reactive-site loops. Here, the crystal structure of PSPI is reported, representing the first heterodimeric double-headed Kunitz-type serine protease inhibitor structure to be determined. PSPI has a beta-trefoil fold and, based on the structure, two reactive-site loops bearing residues Phe75 and Lys95 were identified. | ||
| - | + | Structure of a post-translationally processed heterodimeric double-headed Kunitz-type serine protease inhibitor from potato.,Meulenbroek EM, Thomassen EA, Pouvreau L, Abrahams JP, Gruppen H, Pannu NS Acta Crystallogr D Biol Crystallogr. 2012 Jul;68(Pt 7):794-9. doi:, 10.1107/S090744491201222X. Epub 2012 Jun 15. PMID:22751664<ref>PMID:22751664</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Solanum tuberosum]] | [[Category: Solanum tuberosum]] | ||
| - | [[Category: Meulenbroek, E M | + | [[Category: Meulenbroek, E M]] |
| - | [[Category: Pannu, N S | + | [[Category: Pannu, N S]] |
| - | [[Category: Thomassen, E A.J | + | [[Category: Thomassen, E A.J]] |
[[Category: Beta-trefoil fold]] | [[Category: Beta-trefoil fold]] | ||
[[Category: Hydrolase inhibitor]] | [[Category: Hydrolase inhibitor]] | ||
[[Category: Protease inhibitor]] | [[Category: Protease inhibitor]] | ||
Revision as of 09:50, 4 January 2015
Crystal structure of potato serine protease inhibitor.
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