3rkq
From Proteopedia
(Difference between revisions)
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<StructureSection load='3rkq' size='340' side='right' caption='[[3rkq]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='3rkq' size='340' side='right' caption='[[3rkq]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3rkq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKQ OCA]. <br> | + | <table><tr><td colspan='2'>[[3rkq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RKQ FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NKX2-5, CSX, NKX2.5, NKX2E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NKX2-5, CSX, NKX2.5, NKX2E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rkq RCSB], [http://www.ebi.ac.uk/pdbsum/3rkq PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/NKX25_HUMAN NKX25_HUMAN]] Athyreosis;Familial isolated congenital asplenia;Atrial septal defect - atrioventricular conduction defects;Atrial septal defect, ostium secundum type;Hypoplastic left heart syndrome;Tetralogy of Fallot;Familial atrial fibrillation;Familial progressive cardiac conduction defect;Thyroid hypoplasia;Ventricular septal defect. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | [[http://www.uniprot.org/uniprot/NKX25_HUMAN NKX25_HUMAN]] Athyreosis;Familial isolated congenital asplenia;Atrial septal defect - atrioventricular conduction defects;Atrial septal defect, ostium secundum type;Hypoplastic left heart syndrome;Tetralogy of Fallot;Familial atrial fibrillation;Familial progressive cardiac conduction defect;Thyroid hypoplasia;Ventricular septal defect. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
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Crystal structure of the human NKX2.5 homeodomain in complex with DNA target.,Pradhan L, Genis C, Scone P, Weinberg EO, Kasahara H, Nam HJ Biochemistry. 2012 Aug 14;51(32):6312-9. Epub 2012 Aug 3. PMID:22849347<ref>PMID:22849347</ref> | Crystal structure of the human NKX2.5 homeodomain in complex with DNA target.,Pradhan L, Genis C, Scone P, Weinberg EO, Kasahara H, Nam HJ Biochemistry. 2012 Aug 14;51(32):6312-9. Epub 2012 Aug 3. PMID:22849347<ref>PMID:22849347</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Genis, C | + | [[Category: Genis, C]] |
| - | [[Category: Kasahara, H | + | [[Category: Kasahara, H]] |
| - | [[Category: Nam, H J | + | [[Category: Nam, H J]] |
| - | [[Category: Scone, P | + | [[Category: Scone, P]] |
[[Category: Dna binding]] | [[Category: Dna binding]] | ||
[[Category: Helix-turn-helix]] | [[Category: Helix-turn-helix]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Transcription-dna complex]] | [[Category: Transcription-dna complex]] | ||
Revision as of 10:31, 4 January 2015
NKX2.5 Homeodomain dimer bound to ANF-242 DNA
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