3skn
From Proteopedia
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| - | [[ | + | ==Crystal structure of the RL42 TCR unliganded== |
| + | <StructureSection load='3skn' size='340' side='right' caption='[[3skn]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3skn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SKN FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mi5|1mi5]], [[1kgc|1kgc]], [[1m05|1m05]], [[3ffc|3ffc]], [[3sjv|3sjv]], [[3skm|3skm]], [[3sko|3sko]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3skn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3skn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3skn RCSB], [http://www.ebi.ac.uk/pdbsum/3skn PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | EBV is a ubiquitous and persistent human pathogen, kept in check by the cytotoxic T cell response. In this study, we investigated how three TCRs, which differ in their T cell immunodominance hierarchies and gene usage, interact with the same EBV determinant (FLRGRAYGL), bound to the same Ag-presenting molecule, HLA-B8. We found that the three TCRs exhibit differing fine specificities for the viral Ag. Further, via structural and biophysical approaches, we demonstrated that the viral Ag provides the greatest energetic contribution to the TCR-peptide-HLA interaction, while focusing on a few adjacent HLA-based interactions to further tune fine-specificity requirements. Thus, the TCR engages the peptide-HLA with the viral Ag as the main glue, such that neighboring TCR-MHC interactions are recruited as a supportive adhesive. Collectively, we provide a portrait of how the host's adaptive immune response differentially engages a common viral Ag. | ||
| - | + | A structural basis for varied alphabeta TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule.,Gras S, Wilmann PG, Chen Z, Halim H, Liu YC, Kjer-Nielsen L, Purcell AW, Burrows SR, McCluskey J, Rossjohn J J Immunol. 2012 Jan 1;188(1):311-21. Epub 2011 Dec 2. PMID:22140258<ref>PMID:22140258</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[T-cell receptor|T-cell receptor]] | |
| - | == | + | == References == |
| - | [[ | + | <references/> |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | < | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Burrows, S R | + | [[Category: Burrows, S R]] |
| - | [[Category: Chih, L Yu | + | [[Category: Chih, L Yu]] |
| - | [[Category: Gras, S | + | [[Category: Gras, S]] |
| - | [[Category: Hanim, H | + | [[Category: Hanim, H]] |
| - | [[Category: Kjer-Nielsen, L | + | [[Category: Kjer-Nielsen, L]] |
| - | [[Category: Mccluskey, J | + | [[Category: Mccluskey, J]] |
| - | [[Category: Purcell, A W | + | [[Category: Purcell, A W]] |
| - | [[Category: Rossjohn, J | + | [[Category: Rossjohn, J]] |
| - | [[Category: Wilmann, P G | + | [[Category: Wilmann, P G]] |
| - | [[Category: Zhenjun, C | + | [[Category: Zhenjun, C]] |
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: T cell receptor]] | [[Category: T cell receptor]] | ||
Revision as of 10:47, 4 January 2015
Crystal structure of the RL42 TCR unliganded
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