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3uvk
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3uvk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UVK FirstGlance]. <br> | <table><tr><td colspan='2'>[[3uvk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UVK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uvl|3uvl]], [[3uvm|3uvm]], [[3uvn|3uvn]], [[3uvo|3uvo]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uvl|3uvl]], [[3uvm|3uvm]], [[3uvn|3uvn]], [[3uvo|3uvo]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uvk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uvk RCSB], [http://www.ebi.ac.uk/pdbsum/3uvk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uvk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uvk RCSB], [http://www.ebi.ac.uk/pdbsum/3uvk PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/MLL2_HUMAN MLL2_HUMAN]] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry. | [[http://www.uniprot.org/uniprot/MLL2_HUMAN MLL2_HUMAN]] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
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The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.,Zhang P, Lee H, Brunzelle JS, Couture JF Nucleic Acids Res. 2012 Jan 20. PMID:22266653<ref>PMID:22266653</ref> | The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.,Zhang P, Lee H, Brunzelle JS, Couture JF Nucleic Acids Res. 2012 Jan 20. PMID:22266653<ref>PMID:22266653</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Brunzelle, J S | + | [[Category: Brunzelle, J S]] |
| - | [[Category: Couture, J F | + | [[Category: Couture, J F]] |
| - | [[Category: Lee, H | + | [[Category: Lee, H]] |
| - | [[Category: Zhang, P | + | [[Category: Zhang, P]] |
[[Category: Beta-propeller]] | [[Category: Beta-propeller]] | ||
[[Category: Chromatin biology]] | [[Category: Chromatin biology]] | ||
Revision as of 10:48, 4 January 2015
Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2
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