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2gsk

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[[Image:2gsk.gif|left|200px]]<br /><applet load="2gsk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2gsk.gif|left|200px]]
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caption="2gsk, resolution 2.10&Aring;" />
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'''Structure of the BtuB:TonB Complex'''<br />
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{{Structure
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|PDB= 2gsk |SIZE=350|CAPTION= <scene name='initialview01'>2gsk</scene>, resolution 2.10&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CNC:CO-CYANOCOBALAMIN'>CNC</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene> and <scene name='pdbligand=HEX:HEXANE'>HEX</scene>
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|ACTIVITY=
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|GENE= btuB, bfe, cer, dcrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), tonB, exbA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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}}
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'''Structure of the BtuB:TonB Complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2GSK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CNC:'>CNC</scene>, <scene name='pdbligand=LDA:'>LDA</scene>, <scene name='pdbligand=OCT:'>OCT</scene> and <scene name='pdbligand=HEX:'>HEX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSK OCA].
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2GSK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSK OCA].
==Reference==
==Reference==
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Outer membrane active transport: structure of the BtuB:TonB complex., Shultis DD, Purdy MD, Banchs CN, Wiener MC, Science. 2006 Jun 2;312(5778):1396-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16741124 16741124]
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Outer membrane active transport: structure of the BtuB:TonB complex., Shultis DD, Purdy MD, Banchs CN, Wiener MC, Science. 2006 Jun 2;312(5778):1396-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16741124 16741124]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: tonb]]
[[Category: tonb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:34:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:08:31 2008''

Revision as of 15:08, 20 March 2008

Image:2gsk.gif


PDB ID 2gsk

Drag the structure with the mouse to rotate
, resolution 2.10Å
Ligands: , , , and
Gene: btuB, bfe, cer, dcrC (Escherichia coli), tonB, exbA (Escherichia coli)
Coordinates: save as pdb, mmCIF, xml



Structure of the BtuB:TonB Complex


Overview

In Gram-negative bacteria, the import of essential micronutrients across the outer membrane requires a transporter, an electrochemical gradient of protons across the inner membrane, and an inner membrane protein complex (ExbB, ExbD, TonB) that couples the proton-motive force to the outer membrane transporter. The inner membrane protein TonB binds directly to a conserved region, called the Ton-box, of the transporter. We solved the structure of the cobalamin transporter BtuB in complex with the C-terminal domain of TonB. In contrast to its conformations in the absence of TonB, the Ton-box forms a beta strand that is recruited to the existing beta sheet of TonB, which is consistent with a mechanical pulling model of transport.

About this Structure

2GSK is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Outer membrane active transport: structure of the BtuB:TonB complex., Shultis DD, Purdy MD, Banchs CN, Wiener MC, Science. 2006 Jun 2;312(5778):1396-9. PMID:16741124

Page seeded by OCA on Thu Mar 20 17:08:31 2008

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