2gtl
From Proteopedia
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| - | [[Image:2gtl.gif|left|200px]] | + | [[Image:2gtl.gif|left|200px]] |
| - | + | ||
| - | '''Lumbricus Erythrocruorin at 3.5A resolution''' | + | {{Structure |
| + | |PDB= 2gtl |SIZE=350|CAPTION= <scene name='initialview01'>2gtl</scene>, resolution 3.500Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene> and <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Lumbricus Erythrocruorin at 3.5A resolution''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2GTL is a [ | + | 2GTL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Lumbricus_terrestris Lumbricus terrestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTL OCA]. |
==Reference== | ==Reference== | ||
| - | Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex., Royer WE Jr, Sharma H, Strand K, Knapp JE, Bhyravbhatla B, Structure. 2006 Jul;14(7):1167-77. PMID:[http:// | + | Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex., Royer WE Jr, Sharma H, Strand K, Knapp JE, Bhyravbhatla B, Structure. 2006 Jul;14(7):1167-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16843898 16843898] |
[[Category: Lumbricus terrestris]] | [[Category: Lumbricus terrestris]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: HEM]] | [[Category: HEM]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
| - | [[Category: annelid | + | [[Category: annelid erythrocruorin]] |
[[Category: dihedral d6 symmetry]] | [[Category: dihedral d6 symmetry]] | ||
[[Category: hexagonal bilayer]] | [[Category: hexagonal bilayer]] | ||
[[Category: respiratory protein]] | [[Category: respiratory protein]] | ||
| - | [[Category: triple stranded helical | + | [[Category: triple stranded helical coil]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:08:56 2008'' |
Revision as of 15:08, 20 March 2008
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| , resolution 3.500Å | |||||||
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| Ligands: | , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Lumbricus Erythrocruorin at 3.5A resolution
Overview
Annelid erythrocruorins are highly cooperative extracellular respiratory proteins with molecular masses on the order of 3.6 million Daltons. We report here the 3.5 A crystal structure of erythrocruorin from the earthworm Lumbricus terrestris. This structure reveals details of symmetrical and quasi-symmetrical interactions that dictate the self-limited assembly of 144 hemoglobin and 36 linker subunits. The linker subunits assemble into a core complex with D(6) symmetry onto which 12 hemoglobin dodecamers bind to form the entire complex. Although the three unique linker subunits share structural similarity, their interactions with each other and the hemoglobin subunits display striking diversity. The observed diversity includes design features that have been incorporated into the linker subunits and may be critical for efficient assembly of large quantities of this complex respiratory protein.
About this Structure
2GTL is a Protein complex structure of sequences from Lumbricus terrestris. Full crystallographic information is available from OCA.
Reference
Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex., Royer WE Jr, Sharma H, Strand K, Knapp JE, Bhyravbhatla B, Structure. 2006 Jul;14(7):1167-77. PMID:16843898
Page seeded by OCA on Thu Mar 20 17:08:56 2008
