4ba8
From Proteopedia
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| - | + | ==High resolution NMR structure of the C mu3 domain from IgM== | |
| - | + | <StructureSection load='4ba8' size='340' side='right' caption='[[4ba8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BA8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ba8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ba8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ba8 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | IgM is the first antibody produced during the humoral immune response. Despite its fundamental role in the immune system, IgM is structurally only poorly described. In this work we used X-ray crystallography and NMR spectroscopy to determine the atomic structures of the constant IgM Fc domains (Cmicro2, Cmicro3, and Cmicro4) and to address their roles in IgM oligomerization. Although the isolated domains share the typical Ig fold, they differ substantially in dimerization properties and quaternary contacts. Unexpectedly, the Cmicro4 domain and its C-terminal tail piece are responsible and sufficient for the specific polymerization of Cmicro4 dimers into covalently linked hexamers of dimers. Based on small angle X-ray scattering data, we present a model of the ring-shaped Cmicro4 structure, which reveals the principles of IgM oligomerization. | ||
| - | + | High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.,Muller R, Grawert MA, Kern T, Madl T, Peschek J, Sattler M, Groll M, Buchner J Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10183-8. doi:, 10.1073/pnas.1300547110. Epub 2013 Jun 3. PMID:23733956<ref>PMID:23733956</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Buchner, J | + | [[Category: Buchner, J]] |
| - | [[Category: Graewert, M A | + | [[Category: Graewert, M A]] |
| - | [[Category: Groll, M | + | [[Category: Groll, M]] |
| - | [[Category: Kern, T | + | [[Category: Kern, T]] |
| - | [[Category: Madl, T | + | [[Category: Madl, T]] |
| - | [[Category: Mueller, R | + | [[Category: Mueller, R]] |
| - | [[Category: Peschek, J | + | [[Category: Peschek, J]] |
| - | [[Category: Sattler, M | + | [[Category: Sattler, M]] |
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Immunoglobulin constant region]] | [[Category: Immunoglobulin constant region]] | ||
Revision as of 12:29, 4 January 2015
High resolution NMR structure of the C mu3 domain from IgM
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