4g3j
From Proteopedia
(Difference between revisions)
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| - | + | ==Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [R-VNI-triazole (VNT)]== | |
| - | + | <StructureSection load='4g3j' size='340' side='right' caption='[[4g3j]], [[Resolution|resolution]] 1.83Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[4g3j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3J FirstGlance]. <br> |
| - | [[4g3j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3J OCA]. | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VNT:N-[(1R)-1-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YL)ETHYL]-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZAMIDE'>VNT</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gw9|3gw9]], [[4g7g|4g7g]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP51, Tb11.02.4080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g3j RCSB], [http://www.ebi.ac.uk/pdbsum/4g3j PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Sterol 14-demethylase]] | [[Category: Sterol 14-demethylase]] | ||
[[Category: Trypanosoma brucei]] | [[Category: Trypanosoma brucei]] | ||
| - | [[Category: Hargrove, T Y | + | [[Category: Hargrove, T Y]] |
| - | [[Category: Lepesheva, G I | + | [[Category: Lepesheva, G I]] |
| - | [[Category: Waterman, M R | + | [[Category: Waterman, M R]] |
| - | [[Category: Wawrzak, Z | + | [[Category: Wawrzak, Z]] |
[[Category: Cytochrome p450 fold]] | [[Category: Cytochrome p450 fold]] | ||
[[Category: Cytochrome p450 reductase]] | [[Category: Cytochrome p450 reductase]] | ||
Revision as of 12:34, 4 January 2015
Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [R-VNI-triazole (VNT)]
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Categories: Sterol 14-demethylase | Trypanosoma brucei | Hargrove, T Y | Lepesheva, G I | Waterman, M R | Wawrzak, Z | Cytochrome p450 fold | Cytochrome p450 reductase | Endoplasmic reticulum membrane | Eukaryotic membrane biogenesis | Heme | Monooxygenase | Oxidoreductase-oxidoreductase inhibitor complex | Sterol biosynthesis
