4gie
From Proteopedia
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| - | [[ | + | ==Crystal structure of prostaglandin F synthase from Trypanosoma cruzi bound to NADP== |
| + | <StructureSection load='4gie' size='340' side='right' caption='[[4gie]], [[Resolution|resolution]] 1.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GIE FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fzi|4fzi]], [[4f40|4f40]], [[4g5d|4g5d]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tc00.1047053511287.49 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 Trypanosoma cruzi])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gie RCSB], [http://www.ebi.ac.uk/pdbsum/4gie PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q4DJ07_TRYCC Q4DJ07_TRYCC]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Prostaglandin F synthase|Prostaglandin F synthase]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
| - | [[ | + | |
[[Category: Prostaglandin-F synthase]] | [[Category: Prostaglandin-F synthase]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
[[Category: Bimatoprost]] | [[Category: Bimatoprost]] | ||
[[Category: Chagas disease]] | [[Category: Chagas disease]] | ||
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[[Category: Prostaglandin d2]] | [[Category: Prostaglandin d2]] | ||
[[Category: Rutin]] | [[Category: Rutin]] | ||
| - | [[Category: Seattle structural genomics center for infectious disease]] | ||
[[Category: Ssgcid]] | [[Category: Ssgcid]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Trypanosomiasis]] | [[Category: Trypanosomiasis]] | ||
Revision as of 12:35, 4 January 2015
Crystal structure of prostaglandin F synthase from Trypanosoma cruzi bound to NADP
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