This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2gxb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2gxb.gif|left|200px]]<br /><applet load="2gxb" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2gxb.gif|left|200px]]
-
caption="2gxb, resolution 2.25&Aring;" />
+
 
-
'''Crystal Structure of The Za Domain bound to Z-RNA'''<br />
+
{{Structure
 +
|PDB= 2gxb |SIZE=350|CAPTION= <scene name='initialview01'>2gxb</scene>, resolution 2.25&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
 +
|ACTIVITY=
 +
|GENE= ADAR, ADAR1, DSRAD, IFI4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
}}
 +
 
 +
'''Crystal Structure of The Za Domain bound to Z-RNA'''
 +
 
==Overview==
==Overview==
Line 10: Line 19:
==About this Structure==
==About this Structure==
-
2GXB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GXB OCA].
+
2GXB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GXB OCA].
==Reference==
==Reference==
-
A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17437712 17437712]
+
A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17437712 17437712]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 26: Line 35:
[[Category: za]]
[[Category: za]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:36:16 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:10:13 2008''

Revision as of 15:10, 20 March 2008

Image:2gxb.gif


PDB ID 2gxb

Drag the structure with the mouse to rotate
, resolution 2.25Å
Ligands:
Gene: ADAR, ADAR1, DSRAD, IFI4 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of The Za Domain bound to Z-RNA


Contents

Overview

The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA. Currently, little is known about the detailed structural features of Z-RNA or its involvement in cellular processes. The discovery that certain interferon-response proteins have domains that can stabilize Z-RNA as well as Z-DNA opens the way for the study of Z-RNA. Here, we present the 2.25 A crystal structure of the Zalpha domain of the RNA-editing enzyme ADAR1 (double-stranded RNA adenosine deaminase) complexed to a dUr(CG)(3) duplex RNA. The Z-RNA helix is associated with a unique solvent pattern that distinguishes it from the otherwise similar conformation of Z-DNA. Based on the structure, we propose a model suggesting how differences in solvation lead to two types of Z-RNA structures. The interaction of Zalpha with Z-RNA demonstrates how the interferon-induced isoform of ADAR1 could be targeted toward selected dsRNAs containing purine-pyrimidine repeats, possibly of viral origin.

Disease

Known diseases associated with this structure: Dyschromatosis symmetrica hereditaria OMIM:[601059]

About this Structure

2GXB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:17437712

Page seeded by OCA on Thu Mar 20 17:10:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gxb"
Personal tools