2gx9

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[[Image:2gx9.gif|left|200px]]<br /><applet load="2gx9" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2gx9.gif|left|200px]]
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caption="2gx9, resolution 2.100&Aring;" />
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'''X-ray strucutre of influenza virus NS1 effector domain'''<br />
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{{Structure
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|PDB= 2gx9 |SIZE=350|CAPTION= <scene name='initialview01'>2gx9</scene>, resolution 2.100&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SCN:THIOCYANATE ION'>SCN</scene>
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|ACTIVITY=
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|GENE= Segment 8 - NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11309 unidentified influenza virus])
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}}
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'''X-ray strucutre of influenza virus NS1 effector domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2GX9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus] with <scene name='pdbligand=SCN:'>SCN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GX9 OCA].
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2GX9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GX9 OCA].
==Reference==
==Reference==
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X-ray structure of influenza virus NS1 effector domain., Bornholdt ZA, Prasad BV, Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16715094 16715094]
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X-ray structure of influenza virus NS1 effector domain., Bornholdt ZA, Prasad BV, Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16715094 16715094]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Unidentified influenza virus]]
[[Category: Unidentified influenza virus]]
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[[Category: ns1]]
[[Category: ns1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:36:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:10:14 2008''

Revision as of 15:10, 20 March 2008

Image:2gx9.gif


PDB ID 2gx9

Drag the structure with the mouse to rotate
, resolution 2.100Å
Ligands:
Gene: Segment 8 - NS1 (unidentified influenza virus)
Coordinates: save as pdb, mmCIF, xml



X-ray strucutre of influenza virus NS1 effector domain


Overview

The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.

About this Structure

2GX9 is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.

Reference

X-ray structure of influenza virus NS1 effector domain., Bornholdt ZA, Prasad BV, Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:16715094

Page seeded by OCA on Thu Mar 20 17:10:14 2008

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