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2gyd

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[[Image:2gyd.gif|left|200px]]<br /><applet load="2gyd" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2gyd.gif|left|200px]]
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caption="2gyd, resolution 1.720&Aring;" />
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'''Complex of equine apoferritin with the H-diaziflurane photolabeling reagent'''<br />
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{{Structure
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|PDB= 2gyd |SIZE=350|CAPTION= <scene name='initialview01'>2gyd</scene>, resolution 1.720&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene> and <scene name='pdbligand=DFE:2-(1,1-DIFLUOROETHOXY)-1,1,1-TRIFLUOROETHANE'>DFE</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Complex of equine apoferritin with the H-diaziflurane photolabeling reagent'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2GYD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=DFE:'>DFE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GYD OCA].
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2GYD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GYD OCA].
==Reference==
==Reference==
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Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions., Xi J, Liu R, Rossi MJ, Yang J, Loll PJ, Dailey WP, Eckenhoff RG, ACS Chem Biol. 2006 Jul 21;1(6):377-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17163775 17163775]
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Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions., Xi J, Liu R, Rossi MJ, Yang J, Loll PJ, Dailey WP, Eckenhoff RG, ACS Chem Biol. 2006 Jul 21;1(6):377-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17163775 17163775]
[[Category: Equus caballus]]
[[Category: Equus caballus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: DFE]]
[[Category: DFE]]
[[Category: anesthetic]]
[[Category: anesthetic]]
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[[Category: helical bundles]]
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[[Category: helical bundle]]
[[Category: isoflurane]]
[[Category: isoflurane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:36:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:10:24 2008''

Revision as of 15:10, 20 March 2008

Image:2gyd.gif


PDB ID 2gyd

Drag the structure with the mouse to rotate
, resolution 1.720Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Complex of equine apoferritin with the H-diaziflurane photolabeling reagent


Overview

The difficulty in obtaining binding target and site information for low-affinity drugs, like the inhaled anesthetics, has limited identification of their molecular effectors. Because such information can be provided by photoactive analogues, we designed, synthesized, and characterized a novel diazirnyl haloether that closely mimics isoflurane, the most widely used clinical general anesthetic. This compound, H-diaziflurane, is a nontoxic, potent anesthetic that potentiates GABA-gated ion channels in primary cultures of hippocampal neurons. Calorimetric and structural characterizations show that H-diaziflurane binds a model anesthetic host protein with similar energetics as isoflurane and forms photoadducts with residues lining the isoflurane binding site. H-diaziflurane will be immediately useful for identifying targets and sites important for the molecular pharmacology of the inhaled haloether anesthetics.

About this Structure

2GYD is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions., Xi J, Liu R, Rossi MJ, Yang J, Loll PJ, Dailey WP, Eckenhoff RG, ACS Chem Biol. 2006 Jul 21;1(6):377-84. PMID:17163775

Page seeded by OCA on Thu Mar 20 17:10:24 2008

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