4ijj

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{{STRUCTURE_4ijj| PDB=4ijj | SCENE= }}
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==Structure of transcription factor DksA2 from Pseudomonas aeruginosa==
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===Structure of transcription factor DksA2 from Pseudomonas aeruginosa===
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<StructureSection load='4ijj' size='340' side='right' caption='[[4ijj]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23416301}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ijj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_ucbpp-pa14 Pseudomonas aeruginosa ucbpp-pa14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA14_73020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208963 Pseudomonas aeruginosa UCBPP-PA14])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ijj RCSB], [http://www.ebi.ac.uk/pdbsum/4ijj PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transcription factor DksA contains a four-Cys Zn(2 +)-finger motif thought to be responsible for structural integrity and the relative disposition of its domains. Pseudomonas aeruginosa encodes an additional DksA paralog (DksA2) that is expressed selectively under Zn(2+) limitation. Although DksA2 does not bind Zn(2+), it complements the Escherichia coli dksA deletion and has similar effects on transcription in vitro. In this study, structural and biochemical analyses reveal that DksA2 has a similar fold, domain structure and RNA polymerase binding properties to those of the E. coli DksA despite the lack of the stabilizing metal ion. Structured summary of protein interactions: RNAPandDksA2bindbybiochemical(View interaction) DksAandRNAPbindbybiochemical(View interaction) DksA2andDksA2bindbyX-ray crystallography(View interaction).
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==About this Structure==
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DksA2, a zinc-independent structural analog of the transcription factor DksA.,Furman R, Biswas T, Danhart EM, Foster MP, Tsodikov OV, Artsimovitch I FEBS Lett. 2013 Feb 14. pii: S0014-5793(13)00123-3. doi:, 10.1016/j.febslet.2013.01.073. PMID:23416301<ref>PMID:23416301</ref>
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[[4ijj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_ucbpp-pa14 Pseudomonas aeruginosa ucbpp-pa14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJJ OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Pseudomonas aeruginosa ucbpp-pa14]]
[[Category: Pseudomonas aeruginosa ucbpp-pa14]]
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[[Category: Artsimovitch, I.]]
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[[Category: Artsimovitch, I]]
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[[Category: Biswas, T.]]
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[[Category: Biswas, T]]
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[[Category: Furman, R.]]
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[[Category: Furman, R]]
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[[Category: Tsodikov, O V.]]
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[[Category: Tsodikov, O V]]
[[Category: Disulfide bond]]
[[Category: Disulfide bond]]
[[Category: Dksa fold]]
[[Category: Dksa fold]]

Revision as of 12:55, 4 January 2015

Structure of transcription factor DksA2 from Pseudomonas aeruginosa

4ijj, resolution 3.25Å

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