4g10
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==LigG from Sphingobium sp. SYK-6 is related to the glutathione transferase omega class== |
| + | <StructureSection load='4g10' size='340' side='right' caption='[[4g10]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4g10]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G10 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ligG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=13689 Sphingomonas paucimobilis])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g10 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g10 RCSB], [http://www.ebi.ac.uk/pdbsum/4g10 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | SpLigG is one of the three glutathione transferases (GSTs) involved in the process of lignin breakdown in the soil bacterium Sphingobium sp. SYK-6. Sequence comparisons showed that SpLigG and several proteobacteria homologues form an independent cluster within cysteine-containing GSTs. The relationship between SpLigG and other GSTs was investigated. The X-ray structure and biochemical properties of SpLigG indicate that this enzyme belongs to the omega class of glutathione transferases. However, the hydrophilic substrate binding site of SpLigG, together with its known ability to stereoselectively deglutathionylate the physiological substrate alpha-glutathionyl-beta-hydroxypropiovanillone, argues for broadening the definition of the omega class. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: SpLigG and SpLigGbind by X-ray crystallography (View interaction). | ||
| - | + | Sphingobium sp. SYK-6 LigG involved in lignin degradation is structurally and biochemically related to the glutathione transferase omega class.,Meux E, Prosper P, Masai E, Mulliert G, Dumarcay S, Morel M, Didierjean C, Gelhaye E, Favier F FEBS Lett. 2012 Nov 16;586(22):3944-50. doi: 10.1016/j.febslet.2012.09.036. Epub , 2012 Oct 8. PMID:23058289<ref>PMID:23058289</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Sphingomonas paucimobilis]] | [[Category: Sphingomonas paucimobilis]] | ||
| - | [[Category: Carlin, G Mulliert | + | [[Category: Carlin, G Mulliert]] |
| - | [[Category: Didierjean, C | + | [[Category: Didierjean, C]] |
| - | [[Category: Dumarcay, S | + | [[Category: Dumarcay, S]] |
| - | [[Category: Favier, F | + | [[Category: Favier, F]] |
| - | [[Category: Gelhaye, E | + | [[Category: Gelhaye, E]] |
| - | [[Category: Masai, E | + | [[Category: Masai, E]] |
| - | [[Category: Meux, E | + | [[Category: Meux, E]] |
| - | [[Category: Morel, M | + | [[Category: Morel, M]] |
| - | [[Category: Prosper, P | + | [[Category: Prosper, P]] |
[[Category: Thioredoxin fold]] | [[Category: Thioredoxin fold]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 13:01, 4 January 2015
LigG from Sphingobium sp. SYK-6 is related to the glutathione transferase omega class
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