2h0q

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[[Image:2h0q.jpg|left|200px]]<br /><applet load="2h0q" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2h0q.jpg|left|200px]]
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caption="2h0q, resolution 1.82&Aring;" />
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'''Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)'''<br />
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{{Structure
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|PDB= 2h0q |SIZE=350|CAPTION= <scene name='initialview01'>2h0q</scene>, resolution 1.82&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= STS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2H0Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0Q OCA].
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2H0Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0Q OCA].
==Reference==
==Reference==
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A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17679096 17679096]
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A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17679096 17679096]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: sts-1]]
[[Category: sts-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:37:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:11:09 2008''

Revision as of 15:11, 20 March 2008

Image:2h0q.jpg


PDB ID 2h0q

Drag the structure with the mouse to rotate
, resolution 1.82Å
Gene: STS-1 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)


Overview

Precise signaling by the T cell receptor (TCR) is crucial for a proper immune response. To ensure that T cells respond appropriately to antigenic stimuli, TCR signaling pathways are subject to multiple levels of regulation. Sts-1 negatively regulates signaling pathways downstream of the TCR by an unknown mechanism(s). Here, we demonstrate that Sts-1 is a phosphatase that can target the tyrosine kinase Zap-70 among other proteins. The X-ray structure of the Sts-1 C terminus reveals that it has homology to members of the phosphoglycerate mutase/acid phosphatase (PGM/AcP) family of enzymes, with residues known to be important for PGM/AcP catalytic activity conserved in nature and position in Sts-1. Point mutations that impair Sts-1 phosphatase activity in vitro also impair the ability of Sts-1 to regulate TCR signaling in T cells. These observations reveal a PGM/AcP-like enzyme activity involved in the control of antigen receptor signaling.

About this Structure

2H0Q is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:17679096

Page seeded by OCA on Thu Mar 20 17:11:09 2008

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