4grv
From Proteopedia
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| - | [[ | + | ==The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)== |
| + | <StructureSection load='4grv' size='340' side='right' caption='[[4grv]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4grv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRV FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ntsr1, Ntsr, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4grv RCSB], [http://www.ebi.ac.uk/pdbsum/4grv PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1, a G-protein-coupled receptor (GPCR). In the brain, NTS modulates the activity of dopaminergic systems, opioid-independent analgesia, and the inhibition of food intake; in the gut, NTS regulates a range of digestive processes. Here we present the structure at 2.8 A resolution of Rattus norvegicus NTSR1 in an active-like state, bound to NTS(8-13), the carboxy-terminal portion of NTS responsible for agonist-induced activation of the receptor. The peptide agonist binds to NTSR1 in an extended conformation nearly perpendicular to the membrane plane, with the C terminus oriented towards the receptor core. Our findings provide, to our knowledge, the first insight into the binding mode of a peptide agonist to a GPCR and may support the development of non-peptide ligands that could be useful in the treatment of neurological disorders, cancer and obesity. | ||
| - | + | Structure of the agonist-bound neurotensin receptor.,White JF, Noinaj N, Shibata Y, Love J, Kloss B, Xu F, Gvozdenovic-Jeremic J, Shah P, Shiloach J, Tate CG, Grisshammer R Nature. 2012 Oct 25;490(7421):508-13. doi: 10.1038/nature11558. Epub 2012 Oct 10. PMID:23051748<ref>PMID:23051748</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | |
| - | == | + | == References == |
| - | [[ | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Enterobacteria phage t4]] | [[Category: Enterobacteria phage t4]] | ||
| - | [[Category: Grisshammer, R | + | [[Category: Grisshammer, R]] |
| - | [[Category: Gvozdenovic-Jeremic, J | + | [[Category: Gvozdenovic-Jeremic, J]] |
| - | [[Category: Kloss, B | + | [[Category: Kloss, B]] |
| - | [[Category: Love, J | + | [[Category: Love, J]] |
| - | [[Category: Noinaj, N | + | [[Category: Noinaj, N]] |
| - | [[Category: Shah, P | + | [[Category: Shah, P]] |
| - | [[Category: Shibata, Y | + | [[Category: Shibata, Y]] |
| - | [[Category: Shiloach, J | + | [[Category: Shiloach, J]] |
| - | [[Category: Tate, C G | + | [[Category: Tate, C G]] |
| - | [[Category: White, J F | + | [[Category: White, J F]] |
| - | [[Category: Xu, F | + | [[Category: Xu, F]] |
[[Category: G-protein]] | [[Category: G-protein]] | ||
[[Category: G-protein coupled receptor]] | [[Category: G-protein coupled receptor]] | ||
[[Category: Neurotensin receptor]] | [[Category: Neurotensin receptor]] | ||
[[Category: Signaling protein-agonist complex]] | [[Category: Signaling protein-agonist complex]] | ||
Revision as of 13:49, 4 January 2015
The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)
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