4cq0
From Proteopedia
(Difference between revisions)
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<StructureSection load='4cq0' size='340' side='right' caption='[[4cq0]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='4cq0' size='340' side='right' caption='[[4cq0]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4cq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQ0 OCA]. <br> | + | <table><tr><td colspan='2'>[[4cq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQ0 FirstGlance]. <br> |
- | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SXS:6-AMINO-1,2-BENZOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>SXS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SXS:6-AMINO-1,2-BENZOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>SXS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
- | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr> |
- | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cq0 RCSB], [http://www.ebi.ac.uk/pdbsum/4cq0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cq0 RCSB], [http://www.ebi.ac.uk/pdbsum/4cq0 PDBsum]</span></td></tr> |
- | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref> | [[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref> | ||
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Cyclic Secondary Sulfonamides: Unusually Good Inhibitors of Cancer-Related Carbonic Anhydrase Enzymes.,Moeker J, Peat TS, Bornaghi LF, Vullo D, Supuran CT, Poulsen SA J Med Chem. 2014 Apr 11. PMID:24689792<ref>PMID:24689792</ref> | Cyclic Secondary Sulfonamides: Unusually Good Inhibitors of Cancer-Related Carbonic Anhydrase Enzymes.,Moeker J, Peat TS, Bornaghi LF, Vullo D, Supuran CT, Poulsen SA J Med Chem. 2014 Apr 11. PMID:24689792<ref>PMID:24689792</ref> | ||
- | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Carbonate dehydratase]] | [[Category: Carbonate dehydratase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
- | [[Category: Bornaghi, L F | + | [[Category: Bornaghi, L F]] |
- | [[Category: Moeker, J | + | [[Category: Moeker, J]] |
- | [[Category: Peat, T S | + | [[Category: Peat, T S]] |
- | [[Category: Poulsen, S | + | [[Category: Poulsen, S]] |
- | [[Category: Supuran, C T | + | [[Category: Supuran, C T]] |
- | [[Category: Vullo, D | + | [[Category: Vullo, D]] |
[[Category: Click chemistry]] | [[Category: Click chemistry]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Saccharin]] | [[Category: Saccharin]] |
Revision as of 14:09, 4 January 2015
Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes
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Categories: Carbonate dehydratase | Human | Bornaghi, L F | Moeker, J | Peat, T S | Poulsen, S | Supuran, C T | Vullo, D | Click chemistry | Drug design | Lyase | Saccharin