4fuo
From Proteopedia
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| - | [[ | + | ==Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms== |
| + | <StructureSection load='4fuo' size='340' side='right' caption='[[4fuo]], [[Resolution|resolution]] 1.97Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fuo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis_rp62a Staphylococcus epidermidis rp62a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FUO FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fum|4fum]], [[4fun|4fun]], [[4fup|4fup]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aap, SERP2398 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 Staphylococcus epidermidis RP62A])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fuo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fuo RCSB], [http://www.ebi.ac.uk/pdbsum/4fuo PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | SignificanceUnder adverse environmental conditions, bacteria can form specialized antibiotic-resistant colonies called "biofilms." In Staphylococcus epidermidis biofilms, a protein, Aap, links bacterial cells together but does so only in the presence of zinc ions. We have determined the atomic structure of an adhesive portion of Aap bound to zinc. The protein adopts an elongated, flexible fold with zinc ions bridging two protein chains. The mode of assembly indicates that Aap is likely to form twisted rope-like structures between bacterial cells. These data provide clues about regions of the protein that could be targeted to prevent intercellular adhesion in the developing biofilm. | ||
| - | + | Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms.,Conrady DG, Wilson JJ, Herr AB Proc Natl Acad Sci U S A. 2012 Dec 31. PMID:23277549<ref>PMID:23277549</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Staphylococcus epidermidis rp62a]] | [[Category: Staphylococcus epidermidis rp62a]] | ||
| - | [[Category: Conrady, D G | + | [[Category: Conrady, D G]] |
| - | [[Category: Herr, A B | + | [[Category: Herr, A B]] |
| - | [[Category: Wilson, J J | + | [[Category: Wilson, J J]] |
[[Category: Freestanding beta sheet]] | [[Category: Freestanding beta sheet]] | ||
[[Category: Hydrophilic protein]] | [[Category: Hydrophilic protein]] | ||
Revision as of 14:23, 4 January 2015
Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms
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